Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …

Asplenia (the congenital or acquired absence of the spleen) and hyposplenism (defective
spleen function) are common causes of morbidity and mortality. The spleen is a secondary …

Sickle cell anemia is associated with unusual clinical heterogeneity for a Mendelian
disorder. Fetal hemoglobin concentration and coincident α thalassemia, both which directly …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

The ability to predict the phenotype of an individual with sickle cell anaemia would allow a
reliable prognosis and could guide therapeutic decision making. Some risk factors for …

Sickle cell disease (SCD) is a genetic disease influenced by ethnicity and regional
differences in its clinical course. Recent advances in the management of SCD with newer …

Hyposplenism is not a rare condition and can complicate a remarkable number of illnesses.
The two most time-honored diseases associated with the development of hyposplenism are …

Background Co-inheritance of α-thalassemia was reported to be associated with a delayed
age of disease onset among Cameroonian Sickle Cell Anemia (SCA) patients. The present …

Individuals with sickle cell disease (SCD) demonstrate an increased susceptibility to
invasive bacterial infections (IBI). The most common organisms causing IBI are …

The study estimated α-thalassemia (α-thal) prevalence and assessed its associations with
clinical and hematological features in a random sample of Brazilian children with sickle cell …