Mutant HRas Signaling and Rationale for Use of Farnesyltransferase Inhibitors in Head and Neck Squamous Cell Carcinoma

J Wang, D Al-Majid, JC Brenner, JD Smith - Targeted Oncology, 2023 - Springer
Head and neck squamous cell carcinomas (HNSCCs) are often associated with poor
outcomes, due at least in part to the limited number of treatment options available for those …

New insights into RAS in head and neck cancer

S Jagadeeshan, OZ Novoplansky, O Cohen… - … et Biophysica Acta (BBA …, 2023 - Elsevier
RAS genes are known to be dysregulated in cancer for several decades, and substantial
effort has been dedicated to develop agents that reduce RAS expression or block RAS …

Micropatterning the organization of multicellular structures in 3D biological hydrogels; insights into collective cellular mechanical interactions

B Ergaz, S Goren, A Lesman - Biofabrication, 2023 - iopscience.iop.org
Control over the organization of cells at the microscale level within supporting biomaterials
can push forward the construction of complex tissue architectures for tissue engineering …

Micro-tensile rheology of fibrous gels quantifies strain-dependent anisotropy

S Goren, B Ergaz, D Barak, R Sorkin, A Lesman - Acta Biomaterialia, 2024 - Elsevier
Semiflexible fiber gels such as collagen and fibrin have unique nonlinear mechanical
properties that play an important role in tissue morphogenesis, wound healing, and cancer …

Identification and validation of immune-related gene signature models for predicting prognosis and immunotherapy response in hepatocellular carcinoma

Z Liu, L Yang, C Liu, Z Wang, W Xu, J Lu… - Frontiers in …, 2024 - frontiersin.org
Background This study seeks to enhance the accuracy and efficiency of clinical diagnosis
and therapeutic decision-making in hepatocellular carcinoma (HCC), as well as to optimize …

Evolutionary dynamics of tipifarnib in HRAS mutated head and neck squamous cell carcinoma

S Jagadeeshan, K Suryamohan, N Shin, S Mathukkada… - Oral Oncology, 2024 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) is a highly prevalent malignancy
worldwide, with a significant proportion of patients developing recurrent and/or metastatic …

[HTML][HTML] Tumor-Extrinsic Axl Expression Shapes an Inflammatory Microenvironment Independent of Tumor Cell Promoting Axl Signaling in Hepatocellular Carcinoma

K Breitenecker, D Heiden, T Demmer, G Weber… - International Journal of …, 2024 - mdpi.com
The activation of the receptor tyrosine kinase Axl by Gas6 is a major driver of tumorigenesis.
Despite recent insights, tumor cell-intrinsic and-extrinsic Axl functions are poorly understood …

[HTML][HTML] Inference of long-range cell-cell force transmission from ECM remodeling fluctuations

A Nahum, Y Koren, B Ergaz, S Natan, G Miller… - Communications …, 2023 - nature.com
Cells sense, manipulate and respond to their mechanical microenvironment in a plethora of
physiological processes, yet the understanding of how cells transmit, receive and interpret …

ANXA3, associated with YAP1 regulation, participates in the proliferation and chemoresistance of cervical cancer cells

J Huang, W Wei, F Kang, S Tan, Y Li, X Lu, N Wang - Genes & Genomics, 2023 - Springer
Background Cervical cancer, as one of the most common cancers in women, remains a
major health threat worldwide. Annexin A3 (ANXA3), a component of the annexin family, is …