Mutant HRas Signaling and Rationale for Use of Farnesyltransferase Inhibitors in Head and Neck Squamous Cell Carcinoma
J Wang, D Al-Majid, JC Brenner, JD Smith - Targeted Oncology, 2023 - Springer
Head and neck squamous cell carcinomas (HNSCCs) are often associated with poor
outcomes, due at least in part to the limited number of treatment options available for those …
outcomes, due at least in part to the limited number of treatment options available for those …
New insights into RAS in head and neck cancer
RAS genes are known to be dysregulated in cancer for several decades, and substantial
effort has been dedicated to develop agents that reduce RAS expression or block RAS …
effort has been dedicated to develop agents that reduce RAS expression or block RAS …
Micropatterning the organization of multicellular structures in 3D biological hydrogels; insights into collective cellular mechanical interactions
B Ergaz, S Goren, A Lesman - Biofabrication, 2023 - iopscience.iop.org
Control over the organization of cells at the microscale level within supporting biomaterials
can push forward the construction of complex tissue architectures for tissue engineering …
can push forward the construction of complex tissue architectures for tissue engineering …
Micro-tensile rheology of fibrous gels quantifies strain-dependent anisotropy
Semiflexible fiber gels such as collagen and fibrin have unique nonlinear mechanical
properties that play an important role in tissue morphogenesis, wound healing, and cancer …
properties that play an important role in tissue morphogenesis, wound healing, and cancer …
Identification and validation of immune-related gene signature models for predicting prognosis and immunotherapy response in hepatocellular carcinoma
Z Liu, L Yang, C Liu, Z Wang, W Xu, J Lu… - Frontiers in …, 2024 - frontiersin.org
Background This study seeks to enhance the accuracy and efficiency of clinical diagnosis
and therapeutic decision-making in hepatocellular carcinoma (HCC), as well as to optimize …
and therapeutic decision-making in hepatocellular carcinoma (HCC), as well as to optimize …
Evolutionary dynamics of tipifarnib in HRAS mutated head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a highly prevalent malignancy
worldwide, with a significant proportion of patients developing recurrent and/or metastatic …
worldwide, with a significant proportion of patients developing recurrent and/or metastatic …
[HTML][HTML] Tumor-Extrinsic Axl Expression Shapes an Inflammatory Microenvironment Independent of Tumor Cell Promoting Axl Signaling in Hepatocellular Carcinoma
K Breitenecker, D Heiden, T Demmer, G Weber… - International Journal of …, 2024 - mdpi.com
The activation of the receptor tyrosine kinase Axl by Gas6 is a major driver of tumorigenesis.
Despite recent insights, tumor cell-intrinsic and-extrinsic Axl functions are poorly understood …
Despite recent insights, tumor cell-intrinsic and-extrinsic Axl functions are poorly understood …
[HTML][HTML] Inference of long-range cell-cell force transmission from ECM remodeling fluctuations
Cells sense, manipulate and respond to their mechanical microenvironment in a plethora of
physiological processes, yet the understanding of how cells transmit, receive and interpret …
physiological processes, yet the understanding of how cells transmit, receive and interpret …
ANXA3, associated with YAP1 regulation, participates in the proliferation and chemoresistance of cervical cancer cells
J Huang, W Wei, F Kang, S Tan, Y Li, X Lu, N Wang - Genes & Genomics, 2023 - Springer
Background Cervical cancer, as one of the most common cancers in women, remains a
major health threat worldwide. Annexin A3 (ANXA3), a component of the annexin family, is …
major health threat worldwide. Annexin A3 (ANXA3), a component of the annexin family, is …