Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

Homologous recombination (HR) performs crucial functions including DNA repair,
segregation of homologous chromosomes, propagation of genetic diversity, and …

Homologous recombination is a central pathway to maintain genomic stability and is
involved in the repair of DNA damage and replication fork support, as well as accurate …

DNA lesions cause stalling of DNA replication forks, which can be lethal for the cell.
Homologous recombination (HR) plays an important role in DNA lesion bypass. It is thought …

RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …

Repetitive DNA is present in the eukaryotic genome in the form of segmental duplications,
tandem and interspersed repeats, and satellites. Repetitive sequences can be beneficial by …

Beta human papillomavirus (beta HPV) infections are common in adults. Certain types of
beta HPVs are associated with nonmelanoma skin cancer (NMSC) in immunocompromised …

Most eukaryotes have two Rad51/RecA family recombinases, Rad51, which promotes
recombination during mitotic double‐strand break (DSB) repair, and the meiosis‐specific …

Loss or inactivation of BLM, a helicase of the RecQ family, causes Bloom syndrome, a
genetic disorder with a strong predisposition to cancer. Although the precise function of BLM …

Beta human papillomavirus (β-HPV) are hypothesized to make DNA damage more
mutagenic and potentially more carcinogenic. Double strand breaks (DSBs) are the most …