Advances in new target molecules against schistosomiasis: A comprehensive discussion of physiological structure and nutrient intake

P Zhu, K Wu, C Zhang, SS Batool, A Li, Z Yu… - PLoS …, 2023 - journals.plos.org
Schistosomiasis, a severe parasitic disease, is primarily caused by Schistosoma mansoni,
Schistosoma japonicum, or Schistosoma haematobium. Currently, praziquantel is the only …

Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni

CL Diaz Soria, J Lee, T Chong, A Coghlan… - Nature …, 2020 - nature.com
Over 250 million people suffer from schistosomiasis, a tropical disease caused by parasitic
flatworms known as schistosomes. Humans become infected by free-swimming, water-borne …

Schistosome proteomics: updates and clinical implications

W Castro-Borges, RA Wilson - Expert Review of Proteomics, 2022 - Taylor & Francis
Introduction Schistosomes are long-lived blood dwelling helminth parasites using intricate
mechanisms to invade, mature, and reproduce inside their vertebrate hosts, whilst …

Metagenomic analysis of the intestinal microbiome reveals the potential mechanism involved in Bacillus amyloliquefaciens in treating schistosomiasis japonica in …

H Chen, S Huang, Y Zhao, R Sun, J Wang… - Microbiology …, 2024 - Am Soc Microbiol
Schistosomiasis japonica is one of the neglected tropical diseases characterized by chronic
hepatic, intestinal granulomatous inflammation and fibrosis, as well as dysbiosis of intestinal …

The esophageal gland mediates host immune evasion by the human parasite Schistosoma mansoni

J Lee, T Chong, PA Newmark - Proceedings of the National …, 2020 - National Acad Sciences
Schistosomes are parasitic flatworms that cause schistosomiasis, a neglected tropical
disease affecting over 200 million people. Schistosomes develop multiple body plans while …

The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3

AA Romero, SA Cobb, JNR Collins, SA Kliewer… - PLoS …, 2021 - journals.plos.org
Schistosomes infect over 200 million of the world's poorest people, but unfortunately
treatment relies on a single drug. Nuclear hormone receptors are ligand-activated …

Quantitative Proteomics of Enriched Esophageal and Gut Tissues from the Human Blood Fluke Schistosoma mansoni Pinpoints Secreted Proteins for Vaccine …

LX Neves, RA Wilson, P Brownridge… - Journal of proteome …, 2019 - ACS Publications
Schistosomes are blood-dwelling helminth parasites that cause schistosomiasis, a
debilitating disease resulting in inflammation and, in extreme cases, multiple organ damage …

Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in …

ASA Pereira, MS Amaral… - PLoS neglected …, 2018 - journals.plos.org
Background The possibility of emergence of praziquantel-resistant Schistosoma parasites
and the lack of other effective drugs demand the discovery of new schistosomicidal agents …

Bacillus amyloliquefaciens alleviates the pathological injuries in mice infected with Schistosoma japonicum by modulating intestinal microbiome

H Chen, R Sun, J Wang, S Yao, SS Batool… - Frontiers in Cellular …, 2023 - frontiersin.org
Schistosoma japonicum causes serious pathological organ damage and alteration of the
intestinal microbiome in the mammalian host, threatening the health of millions of people in …

Mapping the epitopes of Schistosoma japonicum esophageal gland proteins for incorporation into vaccine constructs

XH Li, GM Vance, J Cartwright, JP Cao, RA Wilson… - PLoS …, 2020 - journals.plos.org
Background The development of a schistosome vaccine has proved challenging but we
have suggested that characterisation of the self-cure mechanism in rhesus macaques might …