The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota

C Milani, S Duranti, F Bottacini, E Casey… - Microbiology and …, 2017 - Am Soc Microbiol
The human gut microbiota is engaged in multiple interactions affecting host health during
the host's entire life span. Microbes colonize the neonatal gut immediately following birth …

A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome

ME Perez-Muñoz, MC Arrieta, AE Ramer-Tait, J Walter - microbiome, 2017 - Springer
After more than a century of active research, the notion that the human fetal environment is
sterile and that the neonate's microbiome is acquired during and after birth was an accepted …

[HTML][HTML] Microbial exposure during early human development primes fetal immune cells

A Mishra, GC Lai, LJ Yao, TT Aung, N Shental… - Cell, 2021 - cell.com
The human fetal immune system begins to develop early during gestation; however, factors
responsible for fetal immune-priming remain elusive. We explored potential exposure to …

Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery

DM Chu, J Ma, AL Prince, KM Antony, MD Seferovic… - Nature medicine, 2017 - nature.com
Human microbial communities are characterized by their taxonomic, metagenomic and
metabolic diversity, which varies by distinct body sites and influences human physiology …

The not-so-sterile womb: evidence that the human fetus is exposed to bacteria prior to birth

LF Stinson, MC Boyce, MS Payne… - Frontiers in microbiology, 2019 - frontiersin.org
The human microbiome includes trillions of bacteria, many of which play a vital role in host
physiology. Numerous studies have now detected bacterial DNA in first-pass meconium and …

The role of the microbiome for human health: from basic science to clinical applications

MH Mohajeri, RJM Brummer, RA Rastall… - European journal of …, 2018 - Springer
The 2017 annual symposium organized by the University Medical Center Groningen in The
Netherlands focused on the role of the gut microbiome in human health and disease …

The microbiome in early life: implications for health outcomes

S Tamburini, N Shen, HC Wu, JC Clemente - Nature medicine, 2016 - nature.com
Recent studies have characterized how host genetics, prenatal environment and delivery
mode can shape the newborn microbiome at birth. Following this, postnatal factors, such as …

[HTML][HTML] Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid

MC Collado, S Rautava, J Aakko, E Isolauri… - Scientific reports, 2016 - nature.com
Interaction with intestinal microbes in infancy has a profound impact on health and disease
in later life through programming of immune and metabolic pathways. We collected maternal …

Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus

J Wang, J Zheng, W Shi, N Du, X Xu, Y Zhang, P Ji… - Gut, 2018 - gut.bmj.com
Objective The initial colonisation of the human microbiota and the impact of maternal health
on neonatal microbiota at birth remain largely unknown. The aim of our study is to …

The composition of the gut microbiota throughout life, with an emphasis on early life

JM Rodríguez, K Murphy, C Stanton… - Microbial ecology in …, 2015 - Taylor & Francis
The intestinal microbiota has become a relevant aspect of human health. Microbial
colonization runs in parallel with immune system maturation and plays a role in intestinal …