[HTML][HTML] Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain
The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
Microglial subtypes: diversity within the microglial community
Microglia are brain‐resident macrophages forming the first active immune barrier in the
central nervous system. They fulfill multiple functions across development and adulthood …
central nervous system. They fulfill multiple functions across development and adulthood …
[HTML][HTML] Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model
C Käufer, CS Schreiber, AS Hartke, I Denden… - …, 2022 - thelancet.com
Background Neurological symptoms such as cognitive decline and depression contribute
substantially to post-COVID-19 syndrome, defined as lasting symptoms several weeks after …
substantially to post-COVID-19 syndrome, defined as lasting symptoms several weeks after …
[HTML][HTML] A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes
Environmental cues influence the highly dynamic morphology of microglia. Strategies to
characterize these changes usually involve user-selected morphometric features, which …
characterize these changes usually involve user-selected morphometric features, which …
Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission
S Marinelli, B Basilico, MC Marrone… - Seminars in cell & …, 2019 - Elsevier
The continuous crosstalk between microglia and neurons is required for microglia
housekeeping functions and contributes to brain homeostasis. Through these exchanges …
housekeeping functions and contributes to brain homeostasis. Through these exchanges …
[HTML][HTML] Functionalization of brain region-specific spheroids with isogenic microglia-like cells
Current brain spheroids or organoids derived from human induced pluripotent stem cells
(hiPSCs) still lack a microglia component, the resident immune cells in the brain. The …
(hiPSCs) still lack a microglia component, the resident immune cells in the brain. The …
[HTML][HTML] Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases
N Javanmehr, K Saleki, P Alijanizadeh… - Journal of …, 2022 - Springer
Microglia represent the first line of immune feedback in the brain. Beyond immune
surveillance, they are essential for maintaining brain homeostasis. Recent research has …
surveillance, they are essential for maintaining brain homeostasis. Recent research has …
[HTML][HTML] The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes
PK West, AN McCorkindale, B Guennewig… - Journal of …, 2022 - Springer
Background Elevated production of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the
central nervous system (CNS) is implicated in the pathogenesis of neurological diseases …
central nervous system (CNS) is implicated in the pathogenesis of neurological diseases …
Leaky brain in neurological and psychiatric disorders: Drivers and consequences
G Morris, BS Fernandes, BK Puri… - Australian & New …, 2018 - journals.sagepub.com
Background: The blood–brain barrier acts as a highly regulated interface; its dysfunction
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …
[HTML][HTML] Distinct features of brain-resident macrophages: microglia and non-parenchymal brain macrophages
Tissue-resident macrophages play an important role in maintaining tissue homeostasis and
innate immune defense against invading microbial pathogens. Brain-resident macrophages …
innate immune defense against invading microbial pathogens. Brain-resident macrophages …