Colorectal cancer (CRC) ranks as the third most aggressive tumor globally, and it can be
categorized into two forms: colitis-mediated CRC and sporadic CRC. The therapeutic …

Drug repurposing aims to identify new therapeutic uses for drugs that have already been
approved for other conditions. This approach can save time and resources compared to …

Purpose Globally, sepsis, which is a major health issue resulting from severe infection-
induced inflammation, is the fifth biggest cause of death. This research aimed to evaluate, for …

The nephrotoxicity of cisplatin (CIS) is a significant complication that challenges its clinical
applicability. The epithelial to mesenchymal transition (EMT) may be included in the …

Idiopathic pulmonary fibrosis is a progressive, irreversible lung disease that leads to
respiratory failure and death. Vincamine is an indole alkaloid obtained from the leaves of …

Aims Sepsis is a severe inflammatory response to infection with an incidence rate exceeding
48 million cases and 11 million sepsis-related deaths yearly. Furthermore, sepsis remains …

Aim Intrahepatic cholestasis is a common pathological condition of several types of liver
disorders. In this study, we aimed to investigate the regulatory effects of quercetin (QU) on …

Renal ischemia/reperfusion (IR) injury is characterized by an unexpected impairment of
blood flow to the kidney. Azilsartan is an angiotensin receptor blocker that is approved for …

Triple-Negative Breast Cancer (TNBC) is a particularly aggressive subtype among breast
cancers (BCs), characterized by anoikis resistance, high invasiveness, and metastatic …

Despite its clinical value, cisplatin (CISP) is complicated by marked hepatotoxicity via
inducing oxidative stress, inflammatory, and apoptotic pathways. This study aims to explore …