Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation

U Fatima, S Roy, S Ahmad, S Ali, WM Elkady… - Frontiers in …, 2022 - frontiersin.org
Bacopa monnieri has been used for centuries in Ayurvedic medicine, alone or in
combination with other herbs, as a memory and learning enhancer, sedative, and anti …

Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease

K Wagner, L Unger, MM Salman, P Kitchen… - International Journal of …, 2022 - mdpi.com
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …

[HTML][HTML] Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications

U Fatima, S Roy, S Ahmad, LA Al-Keridis… - Biomedicine & …, 2022 - Elsevier
Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda
system; it contains numerous bioactive phytoconstituents implicated in the therapeutic …

Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide

V Montiel, R Bella, LYM Michel, H Esfahani… - Science translational …, 2020 - science.org
Pathological remodeling of the myocardium has long been known to involve oxidant
signaling, but strategies using systemic antioxidants have generally failed to prevent it. We …

Mechanisms of aquaporin-facilitated cancer invasion and metastasis

ML De Ieso, AJ Yool - Frontiers in chemistry, 2018 - frontiersin.org
Cancer is a leading cause of death worldwide, and its incidence is rising with numbers
expected to increase 70% in the next two decades. The fact that current mainline treatments …

Aquaporins: New players in breast cancer progression and treatment response

V Charlestin, D Fulkerson, CE Arias Matus… - Frontiers in …, 2022 - frontiersin.org
Aquaporins (AQPs) are a family of small transmembrane proteins that selectively transport
water and other small molecules and ions following an osmotic gradient across cell plasma …

Divalent cations regulate the ion conductance properties of diverse classes of aquaporins

M Kourghi, S Nourmohammadi, JV Pei, J Qiu… - International journal of …, 2017 - mdpi.com
Aquaporins (AQPs) are known to facilitate water and solute fluxes across barrier
membranes. An increasing number of AQPs are being found to serve as ion channels. Ion …

[HTML][HTML] Aquaporins responses under challenging environmental conditions and abiotic stress tolerance in plants

A Gautam, AK Pandey - The Botanical Review, 2021 - Springer
Aquaporins are important transmembrane channel proteins required for the transport of
water and nutrients to maintain plant water relations and its survival. The aquaporins have a …

The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and …

E Smith, HM Palethorpe, Y Tomita, JV Pei… - Cells, 2018 - mdpi.com
Aquaporin-1 (AQP1), a transmembrane pore-forming molecule, facilitates the rapid
movement of water and small solutes across cell membranes. We have previously shown …

Combined pharmacological administration of AQP1 ion channel blocker AqB011 and water channel blocker Bacopaside II amplifies inhibition of colon cancer cell …

ML De Ieso, JV Pei, S Nourmohammadi, E Smith… - Scientific reports, 2019 - nature.com
Abstract Aquaporin-1 (AQP1) has been proposed as a dual water and cation channel that
when upregulated in cancers enhances cell migration rates; however, the mechanism …