Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

Covering: 2017–2019 Guanidine natural products isolated from microorganisms, marine
invertebrates and terrestrial plants, amphibians and spiders, represented by non-ribosomal …

The total syntheses of selected natural products using different versions of the Ugi
multicomponent reaction is reviewed on a case-by-case basis. The revision covers the …

Small-molecule glycosides that exhibit a β-d-ribosyl residue linked to an aglycone via a
noncanonical C-glycosidic linkage are of great biological importance. They occur naturally …

Epidemic diseases and antibiotic resistance are urgent threats to global health, and human
is confronted with an unprecedented dilemma to conquer them by expediting development …

Pseudouridimycin (1), a potent antibiotic against both Gram-positive and Gram-negative
bacteria including multi-drug-resistant strains with a new mode of action isolated from …

C-Analogues of the canonical N-nucleosides have considerable importance in medicinal
chemistry and are promising building blocks of xenobiotic nucleic acids (XNA) in synthetic …

The Ugi multicomponent reaction represents a highly efficient synthetic transformation,
wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are …

Pseudouridimycin is a microbial C-nucleoside natural product that specifically inhibits
bacterial RNA polymerases by binding to the active site and competing with uridine …

Showdomycin produced by Streptomyces showdoensis ATCC 15227 is a C-nucleoside
microbial natural product with antimicrobial and cytotoxic properties. The unique feature of …