Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney
disease and associated morbidity and mortality. Preclinical research has demonstrated the …

Mitochondria are essential organelles in physiology and kidney diseases, because they
produce cellular energy required to perform their function. During mitochondrial metabolism …

Dyslipidaemia is a hallmark of chronic kidney disease (CKD). The severity of dyslipidaemia
not only correlates with CKD stage but is also associated with CKD-associated …

Renal tubular epithelial cells (RTECs) are one of the most mitochondria-rich cell types, and
are thus vulnerable to mitochondrial dysregulation, which is defined as a pivotal event in …

Mitochondrial defects are implicated in multiple diseases and aging. Exercise training is an
accessible, inexpensive therapeutic intervention that can improve mitochondrial …

Chronic and recurrent infections occur commonly in both type 1 and type 2 diabetes (T1D,
T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes …

The complement system is a part of the immune system and consists of multiple complement
components with biological functions such as defense against pathogens and …

Diabetic nephropathy (DN) is characterized by abnormal kidney energy metabolism, but its
causes and contributions to DN pathogenesis are not clear. To examine this issue, we …

Diabetic nephropathy (DN) is an enduring condition that leads to inflammation and affects a
substantial number of individuals with diabetes worldwide. A gradual reduction in …

The complement system is one of the oldest known tightly regulated host defense systems
evolved for efficiently functioning cell-based immune systems and antibodies. Essentially …