[HTML][HTML] Triple‑negative breast cancer therapy: Current and future perspectives
KA Won, C Spruck - International journal of …, 2020 - … .spandidos-publications.com
Triple‑negative breast cancer (TNBC) accounts for 10‑15% of all breast cancer cases.
TNBCs lack estrogen and progesterone receptors and express low levels of HER2, and …
TNBCs lack estrogen and progesterone receptors and express low levels of HER2, and …
PARP and PARG inhibitors in cancer treatment
D Slade - Genes & development, 2020 - genesdev.cshlp.org
Oxidative and replication stress underlie genomic instability of cancer cells. Amplifying
genomic instability through radiotherapy and chemotherapy has been a powerful but …
genomic instability through radiotherapy and chemotherapy has been a powerful but …
PARP inhibitor resistance: the underlying mechanisms and clinical implications
Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP
inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi …
inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi …
Tumor microenvironment: Challenges and opportunities in targeting metastasis of triple negative breast cancer
KGK Deepak, R Vempati, GP Nagaraju… - Pharmacological …, 2020 - Elsevier
Triple negative breast cancer (TNBC) is most aggressive subtype of breast cancers with high
probability of metastasis as well as lack of specific targets and targeted therapeutics. TNBC …
probability of metastasis as well as lack of specific targets and targeted therapeutics. TNBC …
Insights into new mechanisms and models of cancer stem cell multidrug resistance
Y Garcia-Mayea, C Mir, F Masson, R Paciucci… - Seminars in cancer …, 2020 - Elsevier
The acquisition of genetic alterations, clonal evolution, and the tumor microenvironment
promote cancer progression, metastasis and therapy resistance. These events correspond …
promote cancer progression, metastasis and therapy resistance. These events correspond …
Cancer stem cells and radioresistance: DNA repair and beyond
A Schulz, F Meyer, A Dubrovska, K Borgmann - Cancers, 2019 - mdpi.com
The current preclinical and clinical findings demonstrate that, in addition to the conventional
clinical and pathological indicators that have a prognostic value in radiation oncology, the …
clinical and pathological indicators that have a prognostic value in radiation oncology, the …
[HTML][HTML] BRCA genes: the role in genome stability, cancer stemness and therapy resistance
I Gorodetska, I Kozeretska, A Dubrovska - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …
regulating genome integrity, cell division and death. The integrity of cellular genome is …
Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications
X Zeng, C Liu, J Yao, H Wan, G Wan, Y Li… - Pharmacological …, 2021 - Elsevier
Both hereditary and sporadic breast cancer are suggested to develop from a stem cell
subcomponent retaining most key stem cell properties but with dysregulation of self-renewal …
subcomponent retaining most key stem cell properties but with dysregulation of self-renewal …
[HTML][HTML] Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come?
In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
PARP inhibitors as a therapeutic agent for homologous recombination deficiency in breast cancers
MYT Keung, Y Wu, JV Vadgama - Journal of clinical medicine, 2019 - mdpi.com
Poly (ADP-ribose) polymerases (PARPs) play an important role in various cellular
processes, such as replication, recombination, chromatin remodeling, and DNA repair …
processes, such as replication, recombination, chromatin remodeling, and DNA repair …