Gene drives gaining speed
E Bier - Nature Reviews Genetics, 2022 - nature.com
Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
CRISPR-Cas-based antimicrobials: design, challenges, and bacterial mechanisms of resistance
A Mayorga-Ramos, J Zúñiga-Miranda… - ACS Infectious …, 2023 - ACS Publications
The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …
across the globe. As the discovery of new conventional antibiotics has stalled significantly …
CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering
Existing technologies for site-specific integration of kilobase-sized DNA sequences in
bacteria are limited by low efficiency, a reliance on recombination, the need for multiple …
bacteria are limited by low efficiency, a reliance on recombination, the need for multiple …
Synthetic microbiology in sustainability applications
Microorganisms are a promising means to address many societal sustainability challenges
owing to their ability to thrive in diverse environments and interface with the microscale …
owing to their ability to thrive in diverse environments and interface with the microscale …
Active genetic neutralizing elements for halting or deleting gene drives
CRISPR-Cas9-based gene drive systems possess the inherent capacity to spread
progressively throughout target populations. Here we describe two self-copying (or active) …
progressively throughout target populations. Here we describe two self-copying (or active) …
Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy
KJ Pienta, EU Hammarlund, RH Austin… - Seminars in cancer …, 2022 - Elsevier
Unusually large cancer cells with abnormal nuclei have been documented in the cancer
literature since 1858. For more than 100 years, they have been generally disregarded as …
literature since 1858. For more than 100 years, they have been generally disregarded as …
CRISPR-based antimicrobials to obstruct antibiotic-resistant and pathogenic bacteria
D Palacios Araya, KL Palmer, BA Duerkop - PLoS Pathogens, 2021 - journals.plos.org
The rapid emergence of antibiotic-resistant bacteria and the comparatively limited
development of new antibacterial molecules pose a major threat to modern medicine by …
development of new antibacterial molecules pose a major threat to modern medicine by …
Assessment of a split homing based gene drive for efficient knockout of multiple genes
Homing based gene drives (HGD) possess the potential to spread linked cargo genes into
natural populations and are poised to revolutionize population control of animals. Given that …
natural populations and are poised to revolutionize population control of animals. Given that …
Environmental Galenics: large-scale fortification of extant microbiomes with engineered bioremediation agents
V de Lorenzo - … Transactions of the Royal Society B, 2022 - royalsocietypublishing.org
Contemporary synthetic biology-based biotechnologies are generating tools and strategies
for reprogramming genomes for specific purposes, including improvement and/or creation of …
for reprogramming genomes for specific purposes, including improvement and/or creation of …
Incorporating ecology into gene drive modelling
Gene drive technology, in which fast‐spreading engineered drive alleles are introduced into
wild populations, represents a promising new tool in the fight against vector‐borne diseases …
wild populations, represents a promising new tool in the fight against vector‐borne diseases …