Efferocytosis in health and disease

AC Doran, A Yurdagul Jr, I Tabas - Nature Reviews Immunology, 2020 - nature.com
The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …

Phagocytosis of apoptotic cells in resolution of inflammation

I Kourtzelis, G Hajishengallis, T Chavakis - Frontiers in immunology, 2020 - frontiersin.org
Efficient inflammation resolution is important not only for the termination of the inflammatory
response but also for the restoration of tissue integrity. An integral process to resolution of …

Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA cargo

L Bouchareychas, P Duong, S Covarrubias, E Alsop… - Cell reports, 2020 - cell.com
Developing strategies that promote the resolution of vascular inflammation and
atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes …

Chronic inflammation and cancer; the two sides of a coin

Q Fernandes, VP Inchakalody, T Bedhiafi, S Mestiri… - Life Sciences, 2024 - Elsevier
The correlation between chronic inflammation and cancer was initially identified in the 19th
century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors …

Neutrophil and remnant clearance in immunity and inflammation

A Singhal, S Kumar - Immunology, 2022 - Wiley Online Library
Neutrophil‐centred inflammation and flawed clearance of neutrophils cause and exuberate
multiple pathological conditions. These most abundant leukocytes exhibit very high daily …

The phagocytic code regulating phagocytosis of mammalian cells

TOJ Cockram, JM Dundee, AS Popescu… - Frontiers in …, 2021 - frontiersin.org
Mammalian phagocytes can phagocytose (ie eat) other mammalian cells in the body if they
display certain signals, and this phagocytosis plays fundamental roles in development, cell …

Regulation and functions of 15-lipoxygenases in human macrophages

RG Snodgrass, B Brüne - Frontiers in pharmacology, 2019 - frontiersin.org
Lipoxygenases (LOXs) catalyze the stereo-specific peroxidation of polyunsaturated fatty
acids (PUFAs) to their corresponding hydroperoxy derivatives. Human macrophages …

[HTML][HTML] Resolving inflammation by TAM receptor activation

JP Vago, FA Amaral, FAJ van de Loo - Pharmacology & Therapeutics, 2021 - Elsevier
The control of inflammation is strictly regulated to ensure the adequate intensity and duration
of an inflammatory response, enabling the removal of the trigger factors and the restoration …

Myeloid cell–derived PROS1 inhibits tumor metastasis by regulating inflammatory and immune responses via IL-10

A Maimon, V Levi-Yahid, K Ben-Meir… - The Journal of …, 2021 - Am Soc Clin Investig
Stimulation of TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinases promotes tumor
progression through numerous cellular mechanisms. TAM cognate ligands GAS6 and …

TAM receptors, Phosphatidylserine, inflammation, and Cancer

T Burstyn-Cohen, A Maimon - Cell Communication and Signaling, 2019 - Springer
The numerous and diverse biological roles of Phosphatidylserine (PtdSer) are featured in
this special issue. This review will focus on PtdSer as a cofactor required for stimulating …