Trypanosomes are a group of protozoan eukaryotes, many of which are major parasites of
humans and livestock. The genomes of trypanosomes and their modes of gene expression …

Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this
modification is most pronounced near the beginning of the 3'UTR. We present a perspective …

RNA modifications (epitranscriptome)–such as N6-methyladenosine (m6A), 5-
methylcytosine (m5C), and pseudouridine (Ψ)–modulate RNA processing, stability …

Trypanosomes are protozoan parasites that cycle between insect and mammalian hosts and
are the causative agent of sleeping sickness. Here, we describe the changes of …

The genome of Trypanosoma brucei, the causative agent of African trypanosomiasis, was
published five years ago, yet identification of all genes and their transcripts remains to be …

The ribosome decoding center is rich in modified rRNA nucleotides and little is known about
their effects. Here, we examine the consequences of systematically deleting eight …

H/ACA ribonucleoprotein particles (RNPs) are a family of RNA pseudouridine synthases that
specify modification sites through guide RNAs. They also participate in eukaryotic ribosomal …

The 3D rRNA modification maps database is the first general resource of information about
the locations of modified nucleotides within the 3D structure of the full ribosome, with mRNA …

The parasite Trypanosoma brucei causes African sleeping sickness that is fatal to patients if
untreated. Parasite differentiation from a replicative slender form into a quiescent stumpy …

Ribosomes of trypanosomatids, a family of protozoan parasites causing debilitating human
diseases, possess multiply fragmented rRNAs that together are analogous to 28S rRNA …