The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

Contrary to Warburg's original thesis, accelerated aerobic glycolysis is not a primary,
permanent and universal consequence of dysfunctional or impaired mitochondria …

Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of
cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85 …

Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …

The metabolic characteristics of tumors present considerable hurdles to immune cell
function and cancer immunotherapy. Using a glutamine antagonist, we metabolically …

Currently, the role of the lysosome, endoplasmic reticulum, or dictyosome in the transcription
and translation of programmed cell death ligand 1 (PD‐L1) is well revealed, but the role and …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …

Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …

Interactions between the microbiota and distal gut are fundamental determinants of human
health. Such interactions are concentrated at the colonic mucosa and provide energy for the …