TSPO protein binding partners in bacteria, animals, and plants
C Hiser, BL Montgomery, S Ferguson-Miller - Journal of Bioenergetics and …, 2021 - Springer
The ancient membrane protein TSPO is phylogenetically widespread from archaea and
bacteria to insects, vertebrates, plants, and fungi. TSPO's primary amino acid sequence is …
bacteria to insects, vertebrates, plants, and fungi. TSPO's primary amino acid sequence is …
Insight into the structural features of TSPO: implications for drug development
The translocator protein (TSPO), an 18-kDa transmembrane protein primarily found in the
outer mitochondrial membrane, is evolutionarily conserved and widely distributed across …
outer mitochondrial membrane, is evolutionarily conserved and widely distributed across …
Membrane-mediated ligand unbinding of the PK-11195 ligand from TSPO
The translocator protein (TSPO), previously known as the peripheral benzodiazepine
receptor, is of longstanding medical interest as both a biomarker for neuroinjury and a …
receptor, is of longstanding medical interest as both a biomarker for neuroinjury and a …
Effect of amphiphilic environment on the solution structure of mouse TSPO translocator protein
S Combet, F Bonneté, S Finet, A Pozza, C Saade… - Biochimie, 2023 - Elsevier
The translocator protein (TSPO) is a ubiquitous transmembrane protein of great
pharmacological interest thanks to its high affinity to many drug ligands. The only high …
pharmacological interest thanks to its high affinity to many drug ligands. The only high …
[HTML][HTML] The mutual and dynamic role of TSPO and ligands in their binding process: an example with PK-11195
Translocator protein (TSPO) is an 18 kDa transmembrane protein, localized primarily on the
outer mitochondrial membrane. It has been found to be involved in various physiological …
outer mitochondrial membrane. It has been found to be involved in various physiological …
An in silico, structural, and biological analysis of lactoferrin of different mammals
DS Vieira, RC Polveiro, TJ Butler, TA Hackett… - International journal of …, 2021 - Elsevier
Lactoferrin (LF) belongs to the family of transferrins having multifunctional roles associated
with the immune system of animals. To follow the aims for this study was selected 20 …
with the immune system of animals. To follow the aims for this study was selected 20 …
[HTML][HTML] Structure-Based Drug Design for TSPO: Challenges and Opportunities
The translocator protein 18 kDa (TSPO) is an evolutionarily conserved mitochondrial
transmembrane protein implicated in various neuropathologies and inflammatory conditions …
transmembrane protein implicated in various neuropathologies and inflammatory conditions …
Versatile dimerisation process of translocator protein (TSPO) revealed by an extensive sampling based on a coarse-grained dynamics study
Translocator protein (TSPO), a mitochondrial membrane protein, has been extensively
studied, and its role is still debated and continues to be enigmatic. From a structural …
studied, and its role is still debated and continues to be enigmatic. From a structural …
[HTML][HTML] Enhanced structure/function of mTSPO translocator in lipid: surfactant mixed micelles
C Saade, A Pozza, F Bonneté, S Finet, V Lutz-Bueno… - Biochimie, 2024 - Elsevier
TSPO is a ubiquitous transmembrane protein used as a pharmacological marker in
neuroimaging. The only known atomic structure of mammalian TSPOs comes from the …
neuroimaging. The only known atomic structure of mammalian TSPOs comes from the …
Impact of cholesterol on the stability of monomeric and dimeric forms of the translocator protein TSPO: A molecular simulation study
The translocator protein (TSPO) is a transmembrane protein present across the three
domains of life. Its functional quaternary structure consists of one or more subunits. In mice …
domains of life. Its functional quaternary structure consists of one or more subunits. In mice …