Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis

X Li, S Wei, S Niu, X Ma, H Li, M Jing, Y Zhao - Computers in biology and …, 2022 - Elsevier
Abstract Background Huanglian Jiedu Decoction (HLJDD) is a classical herbal formula with
potential efficacy in the treatment of sepsis. However, the main components and potential …

Pharmacological activity of quercetin: an updated review

G Wang, Y Wang, L Yao, W Gu, S Zhao… - Evidence‐Based …, 2022 - Wiley Online Library
Quercetin, a natural flavonoid compound with a widespread occurrence throughout the plant
kingdom, exhibits a variety of pharmacological activities. Because of the wide spectrum of …

Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways

A Sang, Y Wang, S Wang, Q Wang, X Wang, X Li… - Cellular …, 2022 - Elsevier
Endoplasmic reticulum (ER) stress and mitochondrial dysfunction play a pivotal role in the
pathological process of sepsis-induced acute lung injury (ALI). Quercetin has been proved …

Suppression of lipopolysaccharide‐induced sepsis by tetrahedral framework nucleic acid loaded with quercetin

Z Liu, X Chen, W Ma, Y Gao, Y Yao, J Li… - Advanced Functional …, 2022 - Wiley Online Library
Sepsis has affected millions of people worldwide with high mortality rate and lack of effective
strategies. Previous studies have reported that quercetin (Que) can attenuate …

Quercetin ameliorates nonalcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy

P Cao, Y Wang, C Zhang, MA Sullivan, W Chen… - The Journal of nutritional …, 2023 - Elsevier
The global incidence of nonalcoholic fatty liver disease (NAFLD) has been surging in recent
years, however, no drug is currently approved to treat this disease. Quercetin, a natural …

Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices …

A Karimi, F Naeini, HR Niazkar, H Tutunchi… - Food & function, 2022 - pubs.rsc.org
Sepsis is a severe reaction and excessive immune response to infection, which can lead to
organ dysfunction, and death. This study aimed to investigate the protective effect of nano …

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Y Zhou, C Qian, Y Tang, M Song, T Zhang… - Phytotherapy …, 2023 - Wiley Online Library
Numerous pharmacological effects of quercetin have been illustrated, including
antiinflammation, antioxidation, and anticancer properties. In recent years, the antioxidant …

The potential effects of quercetin-loaded nanoliposomes on amoxicillin/clavulanate-induced hepatic damage: targeting the Sirt1/Nrf2/Nf-κB signaling pathway and …

MM Abd El-Emam, M Mostafa, AA Farag, HS Youssef… - Antioxidants, 2023 - mdpi.com
Amoxicillin/clavulanate (Co-Amox), a commonly used antibiotic for the treatment of bacterial
infections, has been associated with drug-induced liver damage. Quercetin (QR), a naturally …

Effects of luteolin on sepsis: a comprehensive systematic review

M Vajdi, A Karimi, M Karimi, MA Farhangi, G Askari - Phytomedicine, 2023 - Elsevier
Background Sepsis and septic shock are the main causes of mortality and complications in
intensive care units all over the world. Luteolin is thought to have a significant role as a free …

Quercetin alleviates the immunotoxic impact mediated by oxidative stress and inflammation induced by doxorubicin exposure in rats

MR Farag, AAA Moselhy, A El-Mleeh, SH Aljuaydi… - Antioxidants, 2021 - mdpi.com
Doxorubicin (DOX) is a chemotherapeutic agent against hematogenous and solid tumors
with undesirable side effects including immunosuppression. Quercetin (QUR), a natural …