Role of the serrated pathway in colorectal cancer pathogenesis

B Leggett, V Whitehall - Gastroenterology, 2010 - Elsevier
The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …

Systematic review of microsatellite instability and colorectal cancer prognosis

S Popat, R Hubner, RS Houlston - Journal of clinical oncology, 2005 - ascopubs.org
Purpose A number of studies have investigated the relationship between microsatellite
instability (MSI) and colorectal cancer (CRC) prognosis. Although many have reported a …

[HTML][HTML] Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer

CM Ribic, DJ Sargent, MJ Moore… - … England Journal of …, 2003 - Mass Medical Soc
Background Colon cancers with high-frequency microsatellite instability have clinical and
pathological features that distinguish them from microsatellite-stable tumors. We …

ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer

GY Locker, S Hamilton, J Harris, JM Jessup… - Journal of clinical …, 2006 - ascopubs.org
Purpose To update the recommendations for the use of tumor marker tests in the prevention,
screening, treatment, and surveillance of gastrointestinal cancers. Methods For the 2006 …

Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized …

P Maby, D Tougeron, M Hamieh, B Mlecnik, H Kora… - Cancer research, 2015 - AACR
Colorectal cancers with microsatellite instability (MSI) represent 15% of all colorectal
cancers, including Lynch syndrome as the most frequent hereditary form of this disease …

S3-leitlinie–kolorektales karzinom

W Schmiegel, B Buchberger… - Zeitschrift für …, 2017 - thieme-connect.com
2.1 Geltungsbereich und Zweck 2.1. 1. Zielsetzung und Fragestellung Das Kolorektale
Karzinom (KRK) ist mit etwa 64 000 Neuerkrankungen und ca. 26 000 Todesfällen pro Jahr …

Microsatellite instability as a marker of prognosis and response to therapy: a meta-analysis of colorectal cancer survival data

C Guastadisegni, M Colafranceschi, L Ottini… - European journal of …, 2010 - Elsevier
BACKGROUND AND METHODS: We have reviewed and pooled data from published
studies to evaluate the relationship between microsatellite instability (MSI) and colorectal …

Tumor‐infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma

TC Smyrk, P Watson, K Kaul, HT Lynch - Cancer, 2001 - Wiley Online Library
BACKGROUND Cells with deficient DNA mismatch repair develop microsatellite instability.
Extensive microsatellite instability (MSI‐high) is characteristic of colorectal carcinomas in …

Emerging concepts in colorectal neoplasia

JR Jass, VLJ Whitehall, J Young, BA Leggett - Gastroenterology, 2002 - Elsevier
An understanding of the mechanisms that explain the initiation and early evolution of
colorectal cancer should facilitate the development of new approaches to effective …

Microsatellite instability and colorectal cancer prognosis

P Benatti, R Gafà, D Barana, M Marino, A Scarselli… - Clinical Cancer …, 2005 - AACR
Purpose: Many studies have evaluated the role of high levels of microsatellite instability
(MSI) as a prognostic marker and predictor of the response to chemotherapy in colorectal …