The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …

Recent progress in whole-genome mapping and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …

Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Much progress has been made recently in single-cell chromosome conformation capture
technologies. However, a method that allows simultaneous profiling of chromatin …

Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence
variants in the human genome to common traits and diseases. However, translating this …

The cerebellum contains most of the neurons in the human brain and exhibits distinctive
modes of development and aging. In this work, by developing our single-cell three …

Topologically associating domains (TADs) are critical structural units in three-dimensional
genome organization of mammalian genome. Dynamic reorganizations of TADs between …

Abstract Single-cell Hi-C (scHi-C) technologies allow for probing of genome-wide cell-to-cell
variability in three-dimensional (3D) genome organization from individual cells …

The organization of mammalian genomes features a complex, multiscale three-dimensional
(3D) architecture, whose functional significance remains elusive because of limited single …

Determining how chromatin is structured in the nucleus is critical to studying its role in gene
regulation. Recent advances in the analysis of single-cell chromatin architecture have …