Spinal cord stimulation for spasticity: historical approaches, current status, and future directions

SJ Nagel, S Wilson, MD Johnson, A Machado… - … : Technology at the …, 2017 - Elsevier
Introduction Millions of people worldwide suffer with spasticity related to irreversible damage
to the brain or spinal cord. Typical antecedent events include stroke, traumatic brain injury …

Spinal dura mater: biophysical characteristics relevant to medical device development

SJ Nagel, CG Reddy, LA Frizon… - Journal of medical …, 2018 - Taylor & Francis
Understanding the relevant biophysical properties of the spinal dura mater is essential to the
design of medical devices that will directly interact with this membrane or influence the …

Kinematic analysis of the gait of adult sheep during treadmill locomotion: parameter values, allowable total error, and potential for use in evaluating spinal cord injury

S Safayi, ND Jeffery, SK Shivapour… - Journal of the …, 2015 - Elsevier
We are developing a novel intradural spinal cord (SC) stimulator designed to improve the
treatment of intractable pain and the sequelae of SC injury. In-vivo ovine models of …

An ovine model of spinal cord injury

S Wilson, KO Abode-Iyamah, JW Miller… - The journal of spinal …, 2017 - Taylor & Francis
Objective: To develop a large animal model of spinal cord injury (SCI), for use in
translational studies of spinal cord stimulation (SCS) in the treatment of spasticity. We seek …

The hemisection approach in large animal models of spinal cord injury: overview of methods and applications

S Wilson, SJ Nagel, LA Frizon… - Journal of …, 2020 - Taylor & Francis
Introduction: Translating basic science research into a safe and effective therapy for spinal
cord injury (SCI) requires suitable large animal models for testing both implantable devices …

[HTML][HTML] Intradural spinal cord stimulation: performance modeling of a new modality

DJ Anderson, DR Kipke, SJ Nagel… - Frontiers in …, 2019 - frontiersin.org
Introduction: Intradural spinal cord stimulation (SCS) may offer significant therapeutic
benefits for those with intractable axial and extremity pain, visceral pain, spasticity …

Ovine model of neuropathic pain for assessing mechanisms of spinal cord stimulation therapy via dorsal horn recordings, von Frey filaments, and gait analysis

CG Reddy, JW Miller, KO Abode-Iyamah… - Journal of pain …, 2018 - Taylor & Francis
Background It is becoming increasingly important to understand the mechanisms of spinal
cord stimulation (SCS) in alleviating neuropathic pain as novel stimulation paradigms arise …

Treadmill measures of ambulation rates in ovine models of spinal cord injury and neuropathic pain

S Safayi, JW Miller, S Wilson… - Journal of medical …, 2016 - Taylor & Francis
Our laboratories are developing treadmill-based gait analysis employing sheep to
investigate potential efficacy of intra-dural spinal cord stimulation in the treatment of spinal …

Revisiting intradural spinal cord stimulation: an introduction to a novel intradural spinal cord stimulation device

BD Dalm, SV Viljoen, NS Dahdaleh… - Innovative …, 2014 - degruyter.com
Background: Spinal cord stimulation has been in use for decades and is growing as a
therapeutic treatment option. A significant problem arising from the epidural location of the …

Contemporary approaches to preventing and treating infections of novel intrathecal neurostimulation devices

SJ Nagel, L Frizon, T Maiti, AG Machado, GT Gillies… - World neurosurgery, 2019 - Elsevier
Introduction Contemporary approaches to surgical site infections have evolved significantly
over the last several decades in response to the economic pressures of soaring health care …