Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F
subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The …

Cisplatin is a widely prescribed anticancer drug, which triggers cell death by covalent
binding to a broad range of biological molecules. Among cisplatin targets, cellular RNAs …

Given the many roles proposed for Mg2+ in nucleic acids, it is essential to accurately
determine their binding modes. Here, we surveyed the PDB to classify Mg2+ inner-sphere …

A series of pyridinium cation-substituted pleuromutilin analogues were designed,
synthesized and evaluated for their antibacterial activities in vitro and in vivo. Most …

Accurate protein synthesis is determined by the two-subunit ribosome's capacity to
selectively incorporate cognate aminoacyl-tRNA for each mRNA codon. The molecular and …

Nonheme iron dioxygenases catalyze vital reactions for biosystems including the
biosynthesis of antibiotics. One such enzyme, namely the hygromycin biosynthesis enzyme …

Precise knowledge of Mg2+ inner-sphere binding site properties is vital for understanding
the structure and function of nucleic acid systems. Unfortunately, the PDB, which represents …

The ribosome is a large ribonucleoprotein assembly that uses diverse and complex
molecular interactions to maintain proper folding. In vivo assembled ribosomes have been …

Aminoglycoside antibiotics are widely used to treat infectious diseases. Among them,
streptomycin and kanamycin (and derivatives) are of importance to battle multidrug-resistant …

The prediction of biological targets of bioactive molecules from machine-readable materials
can be routinely performed by computational target prediction tools (CTPTs). However, the …