The burden of disease consequent to hepatitis C virus (HCV) infection has been well
described and is expected to increase dramatically over the next decade. Current approved …

With an estimated number of about 180 million affected people worldwide and a limited
therapy option, infection with the hepatitis C virus (HCV) 2 is an important medical problem …

Viruses depend on host-derived factors for their efficient genome replication. Here, we
demonstrate that a cellular peptidyl-prolyl cis-trans isomerase (PPIase), cyclophilin B …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
COVID-19, the disease at the center of the current global pandemic. While knowledge of …

The RNA genomes of plus-strand RNA viruses have the ability to form secondary and higher-
order structures that contribute to their stability and to their participation in inter-and …

RNA is a versatile macromolecule that accommodates functional information in primary
sequence and secondary and tertiary structure. We use a combination of chemical probing …

Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of
liver disease and cancer. The virus has a 9,650-nt, single-stranded, messenger-sense RNA …

Triggering and propagating an intracellular innate immune response is essential for control
of viral infections. RNase L is a host endoribonuclease and a pivotal component of innate …

HCV (hepatitis C virus) infects nearly 3% of the population worldwide and has emerged as a
major causative agent of liver disease, resulting in acute and chronic infections that can lead …

The hepatitis C virus (HCV) has an alternate reading frame (ARF) that overlaps the core
protein gene. The overlapping reading frame distinguishes HCV from all of its known viral …