Chiral molecules containing asymmetric carbon centers bonded with nitrogen are ubiquitous
in nature and also form important structural fragments in both natural and man-made …

Abstract 140 Years ago Adolf von Baeyer proposed the structure of a heteroaromatic
compound which revolutionized organic and medical chemistry: indole. After more than a …

The elaboration of step-economy and catalytic approaches for accessing diverse fluorinated
heterocyclics is highly desirable. Described herein is a radical-polar crossover enabled …

The exploration of privileged structures in drug discovery is a rapidly emerging theme in
medicinal chemistry. These structures represent a class of molecules capable of binding to …

The past few decades have witnessed some of the most important and revolutionizing
advances in the field of asymmetric catalysis. Chemists no longer rely solely on natural …

Catalysis by neutral, organic, small molecules capable of binding and activating substrates
solely via noncovalent interactions—particularly H-bonding—has emerged as an important …

Novel reactions that can selectively functionalize carbon–hydrogen bonds are of intense
interest to the chemical community because they offer new strategic approaches for …

It was found that the phosphoric acid derivatives of general structure 1 serve as highly
effective catalysts for the direct addition of acetyl acetone to N-Boc-protected arylimines. The …

The term “organocatalysis” describes the acceleration of chemical reactions through the
addition of a substoichiometric quantity of an organic compound. The interest in this field has …

This review covers reactions where iminium ions are likely to be active intermediates in the
catalytic cycle. The focus of the review is on synthetically useful protocols and smallmolecule …