Oxytocin (Oxt) is a nonapeptide hormone best known for its role in lactation and parturition.
Since 1906 when its uterine-contracting properties were described until 50 years later when …

Psychiatric disorders are characterized by sex differences in their prevalence,
symptomatology and treatment response. Animal models have been widely employed for …

Rationale: Since the mid-1970s, cross-species translational studies of prepulse inhibition
(PPI) have increased at an astounding pace as the value of this neurobiologically …

Many risk genes interact synergistically to produce schizophrenia and many
neurotransmitter interactions have been implicated. We have developed a circuit-based …

The startle response is composed by a set of reflex behaviors intended to prepare the
organism to face a potentially relevant stimulus. This response can be modulated by several …

This review summarizes evidence of dysregulated reward circuitry function in a range of
neurodevelopmental and psychiatric disorders and genetic syndromes. First, the …

Prepulse inhibition (PPI) is a robust operational measure of sensorimotor gating. In
schizophrenic patients PPI is deficient. The aim of our review was to investigate the state of …

Adenosine kinase (ADK; EC 2.7. 1.20) is an evolutionarily conserved phosphotransferase
that converts the purine ribonucleoside adenosine into 5′-adenosine-monophosphate …

Introduction Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the
startling effects of a subsequent intense abrupt stimulus. This startle-inhibiting effect of the …

In an effort to reveal susceptibility genes, schizophrenia research has turned to the
endophenotype strategy. Endophenotypes are characteristics that reflect the actions of …