Abstract The flavonoids, baicalin (5, 6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-Od-β-
glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants …

Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

In this work we advance the hypothesis that omega-3 (ω-3) long-chain polyunsaturated fatty
acids (LCPUFAs) exhibit cytoprotective and cytotherapeutic actions contributing to a number …

Inflammation in the tumor microenvironment is now recognized as one of the hallmarks of
cancer. Endogenously produced lipid autacoids, locally acting small molecule lipid …

After dissemination from a primary tumor, cancer cells may resume growth, leading to overt
metastasis, or enter a state of protracted dormancy. However, mechanisms that determine …

Cancer is one of the highest prevalent diseases in humans. The chances of surviving cancer
and its prognosis are very dependent on the affected tissue, body location, and stage at …

The metabolism of arachidonic acid through lipoxygenase pathways leads to the generation
of various biologically active eicosanoids. The expression of these enzymes vary throughout …

Hydroxy fatty acids are critical lipid mediators involved in various pathophysiologic functions.
We cloned and identified GPR31, a plasma membrane orphan G protein-coupled receptor …

Extensive studies have implicated the role of dietary fatty acids in prostatecancer
progression. Platelet-type 12-Lipoxygenase (12-LOX) has beenshown to regulate growth …