As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world,
more than 1 billion people, are affected by red cell abnormalities, making them the most …

Platelet activation and blood coagulation are complementary, mutually dependent
processes in haemostasis and thrombosis. Platelets interact with several coagulation …

The membrane raft hypothesis postulates the existence of lipid bilayer membrane
heterogeneities, or domains, supposed to be important for cellular function, including lateral …

The asymmetric phospholipid distribution in plasma membranes is normally maintained by
energy-dependent lipid transporters that translocate different phospholipids from one …

Lipids in biological membranes are asymmetrically distributed across the bilayer; the amine-
containing phospholipids are enriched on the cytoplasmic surface of the plasma membrane …

As platelets aggregate and activate at the site of vascular injury to stem bleeding, they are
subjected to a myriad of biochemical and biophysical signals and cues. As clot formation …

Studies during the last three decades have enabled the development of detailed molecular
insights into the structural basis of altered function in various inherited red cell membrane …

Microvesicles (MVs) released into the brain microenvironment are emerging as a novel way
of cell‐to‐cell communication. We have recently shown that microglia, the immune cells of …

▪ Abstract Maintenance of membrane lipid asymmetry is a dynamic process that influences
many events over the lifespan of the cell. With few exceptions, most cells restrict the bulk of …

This paper reviews the current knowledge on the various mechanisms for transbilayer, or flip-
flop, lipid motion in model and cell membranes, enzyme-assisted lipid transfer by flippases …