The emergence of single-cell multiomics data provides unprecedented opportunities to
scrutinize the transcriptional regulatory mechanisms controlling cell identity. However, how …

With the development of sequencing technology and the dramatic drop in sequencing cost,
the functions of noncoding genes are being characterized in a wide variety of fields (eg …

Enhancers and the enhancer RNAs (eRNAs) have been strongly implicated in regulations of
transcriptions. Based the multi-omics data (ATAC-seq, ChIP-seq and RNA-seq) from public …

Enhancers, genomic DNA elements, regulate neighboring gene expression crucial for
biological processes like cell differentiation and stress response. However, current machine …

Genome-wide association studies (GWAS) and expression analyses implicate noncoding
regulatory regions as harboring risk factors for psychiatric disease, but functional …

Motivation Previous studies have shown that the heritability of multiple brain-related traits
and disorders is highly enriched in transcriptional enhancer regions. However, these …

Recent advances in single-cell transposase-accessible chromatin using a sequencing
assay (scATAC-seq) allow cellular heterogeneity dissection and regulatory landscape …

Background As parts of the cis‐regulatory mechanism of the human genome, interactions
between distal enhancers and proximal promoters play a crucial role. Enhancers, promoters …

Interpreting predictive machine learning models to derive biological knowledge is the
ultimate goal of developing models in the era of genomic data exploding. Recently …