Introduction Covalent drugs have been used for more than hundred years, but gathered
larger interest in the last two decades. There are currently over a 100 different electrophilic …

The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

Targeted covalent inhibitors have become an integral part of a number of therapeutic
protocols and are the subject of intense research. The mechanism of action of these …

Inhibitors that form covalent bonds with their targets have traditionally been considered
highly adventurous due to their potential off-target effects and toxicity concerns. However …

In recent years, the drug discovery paradigm has shifted toward compounds that covalently
modify disease-associated target proteins, because they tend to possess high potency …

Strategies to target specific protein cysteines are critical to covalent probe and drug
discovery. 3-Bromo-4, 5-dihydroisoxazole (BDHI) is a natural product-inspired, synthetically …

Modern drug design aims to discover novel lead compounds with attractable chemical
profiles to enable further exploration of the intersection of chemical space and biological …

This paper introduces RISE, a robust individualized decision learning framework with
sensitive variables, where sensitive variables are collectible data and important to the …

Targeted covalent inhibitors represent a viable strategy to block protein kinases involved in
different disease pathologies. Although a number of computational protocols have been …

Due to their various advantages, interest in the development of covalent drugs has been
renewed in the past few years. It is therefore important to accurately describe and predict …