Major depressive disorder is a chronic, remitting syndrome involving widely distributed
circuits in the brain. Stable alterations in gene expression that contribute to structural and …

Posttranslational modifications (PTMs) modulate protein function in most eukaryotes and
have a ubiquitous role in diverse range of cellular functions. Identification, characterization …

Histone acetylation is a ubiquitous hallmark of transcription, but whether the link between
histone acetylation and transcription is causal or consequential has not been addressed …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Long-term memory formation requires transcription and protein synthesis. Over the past few
decades, a great amount of knowledge has been gained regarding the molecular players …

It has been described that exercise can modulate both inflammatory response and
epigenetic modifications, although the effect of exercise on these parameters during the …

Flowering time of summer annual Arabidopsis thaliana accessions is largely determined by
the timing of FLOWERING LOCUS T (FT) expression in the leaf vasculature. To understand …

Histones are fundamental structural components of chromatin. Eukaryotic DNA is wound
around an octamer of the core histones H2A, H2B, H3, and H4. Binding of linker histone H1 …

Protein acetylation is conserved across phylogeny and has been recognized as one of the
most prominent post-translational modifications since its discovery nearly 60 years ago …

Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …