This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Cell proliferation is orchestrated through diverse proteins related to calcium (Ca 2+)
signaling inside the cell. Cellular Ca 2+ influx that occurs first by various mechanisms at the …

Store-operated Ca2+ entry (SOCE) is a major mechanism of Ca2+ import from extracellular
to intracellular space, involving detection of Ca2+ store depletion in endoplasmic reticulum …

Ca2+ signaling has been increasingly implicated in cancer invasion and metastasis, and
yet, the underlying mechanisms remained largely unknown. In this paper, we report that …

The NFAT signaling pathway regulates various aspects of cellular functions; NFAT acts as a
calcium sensor, integrating calcium signaling with other pathways involved in development …

Tumor metastasis is the major cause of death among cancer patients, with> 90% of cancer-
related death attributable to the spreading of metastatic cells to secondary organs. Store …

Calcium (Ca2+) regulates a plethora of cellular functions including hallmarks of cancer
development such as cell cycle progression and cellular migration. Receptor-regulated …

Inflammation-associated pathways are active in intestinal epithelial cells (IECs) and
contribute to the pathogenesis of colorectal cancer (CRC). Calcineurin, a phosphatase …

Store-operated calcium entry (SOCE) is the predominant calcium entry mechanism in most
cancer cells. SOCE is mediated by the endoplasmic reticulum calcium sensor STIMs (STIM1 …

Background & Aims Oncogenic mutations in KRAS contribute to the development of
pancreatic ductal adenocarcinoma, but are not sufficient to initiate carcinogenesis …