Glutathione in the Brain

K Aoyama - International journal of molecular sciences, 2021 - mdpi.com
Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the
antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH …

[HTML][HTML] Pesticide toxicity: a mechanistic approach

VI Lushchak, TM Matviishyn, VV Husak, JM Storey… - EXCLI …, 2018 - ncbi.nlm.nih.gov
Pesticides are known for their high persistence and pervasiveness in the environment, and
along with products of their biotransformation, they may remain in and interact with the …

Fish bioaccumulation and biomarkers in environmental risk assessment: a review

R Van der Oost, J Beyer, NPE Vermeulen - Environmental toxicology and …, 2003 - Elsevier
In this review, a wide array of bioaccumulation markers and biomarkers, used to
demonstrate exposure to and effects of environmental contaminants, has been discussed in …

Metabolism and functions of glutathione in brain

R Dringen - Progress in neurobiology, 2000 - Elsevier
The tripeptide glutathione is the thiol compound present in the highest concentration in cells
of all organs. Glutathione has many physiological functions including its involvement in the …

Chemistry of biologically important synthetic organoselenium compounds

G Mugesh, WW du Mont, H Sies - Chemical reviews, 2001 - ACS Publications
The element selenium was discovered in 1818 by the Swedish chemist Berzelius and was
named after the Greek goddess of the moon, Selene. 1 In biology, selenium was long …

Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches

JGM Bessems, NPE Vermeulen - Critical reviews in toxicology, 2001 - Taylor & Francis
An overview is presented on the molecular aspects of toxicity due to paracetamol
(acetaminophen) and structural analogues. The emphasis is on four main topics, that is …

The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites

RL Edwards, PB Luis, PV Varuzza, AI Joseph… - Journal of Biological …, 2017 - ASBMB
The spice turmeric, with its active polyphenol curcumin, has been used as anti-inflammatory
remedy in traditional Asian medicine for centuries. Many cellular targets of curcumin have …

Pathways and regulation of sulfur metabolism revealed through molecular and genetic studies

T Leustek, MN Martin, JA Bick… - Annual review of plant …, 2000 - annualreviews.org
▪ Abstract Sulfur is essential for life. Its oxidation state is in constant flux as it circulates
through the global sulfur cycle. Plants play a key role in the cycle since they are primary …

Glutathione pathways in the brain

R Dringen, J Hirrlinger - 2003 - degruyter.com
The antioxidant glutathione (GSH) is essential for the cellular detoxification of reactive
oxygen species in brain cells. A compromised GSH system in the brain has been connected …

Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants: evidence for …

F Ali-Osman, O Akande, G Antoun, JX Mao… - Journal of biological …, 1997 - ASBMB
We report the isolation of three full-length cDNAs corresponding to the mRNAs of closely
related glutathione S-transferase (GST) Pi genes, designated hGSTP1* A, hGSTP1* B, and …