Giardia duodenalis: biology and pathogenesis

RD Adam - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Giardia duodenalis captured the attention of Leeuwenhoek in 1681 while he was examining
his own diarrheal stool, but, ironically, it did not really gain attention as a human pathogen …

Molecular epidemiology of Giardia infections in the genomic era

P Capewell, S Krumrie, F Katzer, CL Alexander… - Trends in …, 2021 - cell.com
Giardia duodenalis is a major gastrointestinal parasite of humans and animals across the
globe. It is also of interest from an evolutionary perspective as it possesses many features …

Giardia duodenalis

L Rojas-López, RC Marques, SG Svärd - Trends in Parasitology, 2022 - cell.com
Giardia duodenalis (syn. Giardia lamblia and Giardia intestinalis) is a major cause of
parasite-induced diarrheal disease. It is found worldwide but the prevalence is higher in low …

[HTML][HTML] Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics

B Balan, SJ Emery-Corbin, JJ Sandow… - International Journal for …, 2021 - Elsevier
Cyst formation in the parasitic protist Giardia duodenalis is critical to its transmission.
Existing proteomic data quantifies only 17% of coding genes transcribed during encystation …

High Cysteine Membrane Proteins (HCMPs) Are Up-Regulated During Giardia-Host Cell Interactions

D Peirasmaki, SY Ma'ayeh, F Xu, M Ferella… - Frontiers in …, 2020 - frontiersin.org
Giardia intestinalis colonizes the upper small intestine of humans and animals, causing the
diarrheal disease giardiasis. This unicellular eukaryotic parasite is not invasive but it …

[HTML][HTML] Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical …

CS Saghaug, AL Gamlem, KB Hauge… - International Journal for …, 2023 - Elsevier
The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia
is dependent on its activation/inactivation within the cytoplasm. There are several activating …

Spliceosomal introns in the diplomonad parasite Giardia duodenalis revisited

MH Seabolt, DM Roellig… - Microbial …, 2023 - microbiologyresearch.org
Complete reference genomes, including correct feature annotations, are a fundamental
aspect of genomic biology. In the case of protozoan species such as Giardia duodenalis, a …

[HTML][HTML] Nourseothricin as a novel drug for selection of transgenic Giardia lamblia

CD Wirdnam, D Warmus, C Faso - International Journal for Parasitology …, 2024 - Elsevier
Functional gene and protein characterizations in parasitic protists are often limited by their
genetic tractability. Despite the development of CRISPR-Cas9-derived or inspired …

Implementation of a tunable t-CRISPRi system for gene regulation in Giardia duodenalis

E García-Huerta, S Espinoza-Corona… - Plasmid, 2022 - Elsevier
Giardia duodenalis, is a binuclear and microaerophilic protozoan that causes giardiasis. Up
to date, several molecular approaches have been taken to understand the molecular …

Oxygen levels are key to understanding “Anaerobic” protozoan pathogens with micro-aerophilic lifestyles

D Lloyd, A Chapman, JE Ellis, K Hillman… - Advances in Microbial …, 2021 - Elsevier
Publications abound on the physiology, biochemistry and molecular biology of “anaerobic”
protozoal parasites as usually grown under “anaerobic” culture conditions. The media …