When a protein's function cannot be experimentally determined, it can often be inferred from
sequence similarity. Should this process fail, analysis of the protein structure can provide …

Enzymes have been shaped by evolution over billions of years to catalyse the chemical
reactions that support life on earth. Dispersed in the literature, or organised in online …

We discuss basic physical–chemical principles underlying the formation of stable
macromolecular complexes, which in many cases are likely to be the biological units …

A novel stereo matching algorithm is proposed that utilizes color segmentation on the
reference image and a self-adapting matching score that maximizes the number of reliable …

Motivation: All residues in a protein are not equally important. Some are essential for the
proper structure and function of the protein, whereas others can be readily replaced …

Identifying a protein's functional sites is an important step towards characterizing its
molecular function. Numerous structure-and sequence-based methods have been …

Identifying active site residues strictly from protein three-dimensional structure is a difficult
task, especially for proteins that have few or no homologues. We transformed protein …

Annotating active sites in enzymes is crucial for advancing multiple fields including drug
discovery, disease research, enzyme engineering, and synthetic biology. Despite the …

The assumption that crystal contacts reflect natural macromolecular interactions makes a
basis for many studies in structural biology. However, the crystal state may correspond to a …

Enzymes are crucial in numerous biological processes, with the Enzyme Commission (EC)
number being a commonly used method for defining enzyme function. However, current EC …