The gut–liver axis and the intersection with the microbiome

A Tripathi, J Debelius, DA Brenner, M Karin… - Nature reviews …, 2018 - nature.com
In the past decade, an exciting realization has been that diverse liver diseases—ranging
from nonalcoholic steatohepatitis, alcoholic steatohepatitis and cirrhosis to hepatocellular …

Redox active cerium oxide nanoparticles: current status and burning issues

MS Lord, JF Berret, S Singh, A Vinu, AS Karakoti - Small, 2021 - Wiley Online Library
Research on cerium oxide nanoparticles (nanoceria) has captivated the scientific community
due to their unique physical and chemical properties, such as redox activity and oxygen …

[HTML][HTML] Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/inflammation …

AA Hamza, GH Heeba, S Hamza, A Abdalla… - Biomedicine & …, 2021 - Elsevier
Ginger has been proposed as quite a promising candidate for cancer prevention. The
purpose of this study was to assess the chemo-preventive effects of ginger. Furthermore, this …

Gut microbiota in phytopharmacology: A comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions

P Dey - Pharmacological research, 2019 - Elsevier
The dynamic and delicate interactions amongst intestinal microbiota, metabolome and
metabolism dictates human health and disease. In recent years, our understanding of gut …

[HTML][HTML] GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma

Z Wang, L He, W Li, C Xu, J Zhang… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background A better understanding of the molecular mechanisms that manifest in the
immunosuppressive tumor microenvironment (TME) is crucial for developing more …

Combining crocin and sorafenib improves their tumor-inhibiting effects in a rat model of diethylnitrosamine-induced cirrhotic-hepatocellular carcinoma

B Awad, AA Hamza, A Al-Maktoum, S Al-Salam, A Amin - Cancers, 2023 - mdpi.com
Simple Summary Liver cancer represents one of the most lethal forms of cancer, with
hepatocellular carcinoma (HCC) accounting for the majority of its incidences and deaths …

Animal and organoid models of liver fibrosis

Y Bao, L Wang, H Pan, T Zhang, Y Chen, S Xu… - Frontiers in …, 2021 - frontiersin.org
Liver fibrosis refers to the process underlying the development of chronic liver diseases,
wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive …

Therapeutic effects of crocin alone or in combination with sorafenib against hepatocellular carcinoma: in vivo & in vitro insights

S Abdu, N Juaid, A Amin, M Moulay, N Miled - Antioxidants, 2022 - mdpi.com
This study investigated the therapeutic effects of the phytochemical crocin alone or in
combination with sorafenib both in rats chemically induced with hepatocellular carcinoma …

6‐Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine‐Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti‐Inflammatory …

MA Alsahli, SA Almatroodi, A Almatroudi… - Mediators of …, 2021 - Wiley Online Library
Diethylnitrosamine (DEN) is a well‐known hepatocarcinogen, and its oral administration
causes severe liver damage including cancer. DEN induces the pathogenesis of the liver …

Nitrosamine contamination in pharmaceuticals: threat, impact, and control

B Tuesuwan, V Vongsutilers - Journal of Pharmaceutical Sciences, 2021 - Elsevier
Nitrosamine-contaminated medicinal products have raised safety concerns towards the use
of various drugs, not only valsartan and all tetrazole-containing angiotensin II receptor …