Alzheimer's disease (AD) is the leading cause of dementia and the most common
neurodegenerative disorder. AD is mostly a sporadic disorder and its main risk factor is age …

Alzheimer's disease (AD) is the most epidemic neuronal dysfunctions among elderly people.
It is accompanied by neuronal disorders along with learning and memory defects, as well as …

Transient oligomeric species formed during the aggregation process of the 42-residue form
of the amyloid-β peptide (Aβ42) are key pathogenic agents in Alzheimer's disease (AD). To …

The timescale for the microscopic dynamics of proteins during conformational transitions is
set by the intrachain diffusion coefficient, D. Despite the central role of protein misfolding and …

Seeded propagation of amyloid-beta (Aβ) pathology is suggested to contribute to the
progression of Alzheimer's disease. Local overproduction of aggregation-prone Aβ variants …

DNA double-strand breaks occur in many acute and long-term neurological conditions,
including neurodegeneration, neurotrauma, and stroke. Nonrepaired breaks chronically …

Abstract α-Synuclein is a protein that aggregates as amyloid fibrils in the brains of patients
with Parkinson's disease and dementia with Lewy bodies. Small oligomers of α-synuclein …

Alzheimer's disease (AD) is the most common form of dementia, impairing cognitive and
motor functions. One of the pathological hallmarks of AD is neuronal loss, which is not …

Amyloid-β (Aβ) proteotoxicity is associated with Alzheimer's disease (AD) and is caused by
protein aggregation, resulting in neuronal damage in the brain. In the search for novel …

Alzheimer's disease (AD) is the most common form of dementia and is characterized by
intracellular neurofibrillary tangles of hyperphosphorylated Tau, including the 0N4R isoform …