Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

Significant progress has been made in developing new treatments and refining the use of
preexisting ones against cancer. Their successful use and the longer survival of cancer …

Background—Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs)
monolayers generated to date display an immature embryonic-like functional and structural …

Recent clinical investigations indicate that anthracycline-based chemotherapies induce
early decline in heart mass in cancer patients. Heart mass decline may be caused by a …

Doxorubicin (DOX)-induced cardiotoxicity seriously limits its clinical applicability, and no
therapeutic interventions are available. Ferroptosis, an iron-dependent regulated cell death …

With the rapid increase in cancer survival because of improved diagnosis and therapy in the
past decades, cancer treatment–related cardiotoxicity is becoming an urgent healthcare …

Chemotherapy has been reported to upregulate sphingomylinases and increase cellular
ceramide, often linked to the induction to cell death. In this work, we show that sublethal …

Abstract Aims Doxorubicin (Dox) is a potent anticancer agent that is widely used in the
treatment of a variety of cancers, but its usage is limited by cumulative dose-dependent …

Autophagy is an evolutionarily conserved intracellular degradation/recycling system that is
essential for cellular homeostasis but is dysregulated in a number of diseases, including …

Radiation therapy (RT) is commonly used to treat solid tumors of the breast, lung, and
esophagus; however, the heart is an unintentional target of ionizing radiation (IR). IR …