Major histocompatibility complex genomics and human disease

J Trowsdale, JC Knight - Annual review of genomics and human …, 2013 - annualreviews.org
Over several decades, various forms of genomic analysis of the human major
histocompatibility complex (MHC) have been extremely successful in picking up many …

A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC

PIW De Bakker, G McVean, PC Sabeti, MM Miretti… - Nature …, 2006 - nature.com
The proteins encoded by the classical HLA class I and class II genes in the major
histocompatibility complex (MHC) are highly polymorphic and are essential in self versus …

PyPop update–a software pipeline for large‐scale multilocus population genomics

AK Lancaster, RM Single, OD Solberg, MP Nelson… - 2007 - Wiley Online Library
Population genetic statistics from multilocus genotype data inform our understanding of the
patterns of genetic variation and their implications for evolutionary studies, generally, and …

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

MA Ansari, V Pedergnana, C LC Ip, A Magri… - Nature …, 2017 - nature.com
Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host
genetic factors. Here we use human genome-wide genotyping arrays and new whole …

[HTML][HTML] Immune system regulation and role of the human leukocyte antigen in posttraumatic stress disorder

S Katrinli, AK Smith - Neurobiology of Stress, 2021 - Elsevier
Posttraumatic stress disorder (PTSD) is a debilitating condition that adversely affect mental
and physical health. Recent studies have increasingly explored the role of the immune …

MHC haplotype matching for unrelated hematopoietic cell transplantation

EW Petersdorf, M Malkki, TA Gooley, PJ Martin… - PLoS …, 2007 - journals.plos.org
Background Current criteria for the selection of unrelated donors for hematopoietic cell
transplantation (HCT) include matching for the alleles of each human leukocyte antigen …

Genetic diversity revealed in human faces

HC Lie, G Rhodes, LW Simmons - Evolution, 2008 - academic.oup.com
From an evolutionary perspective, human facial attractiveness is proposed to signal mate
quality. Using a novel approach to the study of the genetic basis of human preferences for …

A statistical method for predicting classical HLA alleles from SNP data

S Leslie, P Donnelly, G McVean - The American Journal of Human …, 2008 - cell.com
Genetic variation at classical HLA alleles is a crucial determinant of transplant success and
susceptibility to a large number of infectious and autoimmune diseases. However, large …

HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection

KA McAulay, CD Higgins, KF Macsween… - The Journal of …, 2007 - Am Soc Clin Investig
Infectious mononucleosis (IM) is an immunopathological disease caused by EBV that occurs
in young adults and is a risk factor for Hodgkin lymphoma (HL). An association between EBV …

Multi-SNP analysis of MHC region: remarkable conservation of HLA-A1-B8-DR3 haplotype

TA Aly, E Eller, A Ide, K Gowan, SR Babu, HA Erlich… - Diabetes, 2006 - Am Diabetes Assoc
Technology has become available to cost-effectively analyze thousands of single nucleotide
polymorphisms (SNPs). We recently confirmed by genotyping a small series of class I alleles …