Despite advances in surgery, radiotherapy, and chemotherapy, glioblastoma (GBM) remains
a malignancy with poor prognosis. The molecular profile of GBM is diverse across patients …

L-methioninase degrades methionine, which is essential in methionine-dependent cancer
cells, resulting in specific cell death. Normal cells can synthesize their own methionine …

Despite recent advances in the treatment of malignant gliomas (World Health Organization
grade III and grade IV tumors-Glioblastoma Multiforme, Anaplastic Astrocytoma and …

Background Glioblastoma subtypes have been defined based on transcriptional profiling,
yet personalized care based on molecular classification remains unexploited …

Glutathione transferases (GSTs) are often overexpressed in tumors and frequently
correlated to bad prognosis and resistance against a number of different anticancer drugs …

Aims: We explore the role of an elevated O2−: H2O2 ratio as a prosurvival signal in glioma-
propagating cells (GPCs). We hypothesize that depleting this ratio sensitizes GPCs to …

Rapidly dividing cells maintain chromatin supercoiling homeostasis via two specialized
classes of enzymes, DNA topoisomerase type 1 and 2 (TOP1/2). Several important …

Glioblastoma (GBM), the highest grade astrocytoma, is one of the most aggressive and
challenging cancers to treat. The standard treatment is usually limited due to the intrinsic …

The authors report on a case of concurrent herpes simplex encephalitis (HSE) and
malignant glioma. The co-occurrence of HSE and malignant glioma is very rare, but it can …

In general, the field of cancer genetics seems to have shifted its focus from cancer-
associated genes to cancer-associated epigenetic activity. An abundance of evidence …