The known unknowns: an overview of the state of blood-based protein biomarkers of mild traumatic brain injury

SJ McDonald, SR Shultz, DV Agoston - Journal of Neurotrauma, 2021 - liebertpub.com
Blood-based protein biomarkers have revolutionized several fields of medicine by enabling
molecular level diagnosis, as well as monitoring disease progression and treatment efficacy …

The immune system's role in the consequences of mild traumatic brain injury (concussion)

LN Verboon, HC Patel, AD Greenhalgh - Frontiers in immunology, 2021 - frontiersin.org
Mild traumatic brain injury (mild TBI), often referred to as concussion, is the most common
form of TBI and affects millions of people each year. A history of mild TBI increases the risk of …

Characterizing head impact exposure in men and women during boxing and mixed martial arts

AE Jansen, M McGrath, S Samorezov… - … journal of sports …, 2021 - journals.sagepub.com
Background: The accumulation of subconcussive impacts has been implicated in permanent
neurological impairment. A gap in understanding the relationship between head impacts …

Treatment with the vascular endothelial growth factor-A antibody, bevacizumab, has sex-specific effects in a rat model of mild traumatic brain injury

M Sun, TL Baker, CT Wilson, RD Brady… - Journal of Cerebral …, 2024 - journals.sagepub.com
Mild traumatic brain injury (mTBI) involves damage to the cerebrovascular system. Vascular
endothelial growth factor-A (VEGF-A) is an important modulator of vascular health and VEGF …

Blood-based biomarkers of repetitive, subconcussive blast overpressure exposure in the training environment: a pilot study

DV Agoston, J McCullough, R Aniceto, IH Lin… - Neurotrauma …, 2022 - liebertpub.com
Because of their unknown long-term effects, repeated mild traumatic brain injuries (TBIs),
including the low, subconcussive ones, represent a specific challenge to healthcare …

Targeting the cerebrovascular system: next-generation biomarkers and treatment for mild traumatic brain injury

TL Baker, DV Agoston, RD Brady, B Major… - The …, 2022 - journals.sagepub.com
The diagnosis, prognosis, and treatment of mild traumatic brain injuries (mTBIs), such as
concussions, are significant unmet medical issues. The kinetic forces that occur in mTBI …

Elevated serum interleukin-1β levels in male, but not female, collision sport athletes with a concussion history

WT O'Brien, GF Symons, J Bain, BP Major… - Journal of …, 2021 - liebertpub.com
It is increasingly reported that a history of concussion may be associated with chronic
deleterious consequences. While the pathophysiology that contributes to these …

Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam

PG Saletti, WB Mowrey, W Liu, Q Li… - Epilepsia …, 2023 - Wiley Online Library
Objective We used the lateral fluid percussion injury (LFPI) model of moderate‐to‐severe
traumatic brain injury (TBI) to identify early plasma biomarkers predicting injury, early post …

Concussion and long‐term cognitive function among rugby players—The BRAIN Study

V Gallo, DM McElvenny, G Seghezzo… - Alzheimer's & …, 2022 - Wiley Online Library
Abstract Objective The BRAIN Study was established to assess the associations between
self‐reported concussions and cognitive function among retired rugby players. Methods …

Decrease in plasma miR-27a and miR-221 after concussion in Australian football players

SR Shultz, CJ Taylor, R Aggio-Bruce… - Biomarker …, 2022 - journals.sagepub.com
Introduction: Sports-related concussion (SRC) is a common form of brain injury that lacks
reliable methods to guide clinical decisions. MicroRNAs (miRNAs) can influence biological …