The geometry of porous scaffolds that are used for bone tissue engineering and/or bone
substitution has recently been shown to significantly influence the cellular response and the …

The controlled delivery of growth factors and cells within biomaterial carriers can enhance
and accelerate functional bone formation. The carrier system can be designed with pre …

Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New
blood vessel formation is crucial during both primary bone development as well as fracture …

The repair of large bone defects remains a major clinical orthopaedic challenge. Bone is a
highly vascularised tissue reliant on the close spatial and temporal connection between …

The treatment of challenging fractures and large osseous defects presents a formidable
problem for orthopaedic surgeons. Tissue engineering/regenerative medicine approaches …

Regeneration of bone and cartilage defects can be accelerated by localized delivery of
appropriate growth factors incorporated within biodegradable carriers. The carrier …

As life expectancy increases, malfunction or loss of tissue caused by injury or disease leads
to reduced quality of life in many patients at significant socioeconomic cost. Even though …

MicroComputed Tomography has become the gold standard for studying 3D microscopic
structures nondestructively, and this book provides up-to-date coverage of the modality. The …

Infection is a common complication of open fractures. Systemic antibiotics often cause
adverse events before eradication of infected bone occurs. The local delivery of antibiotics …

The medical community has expressed significant interest in the development of new types
of artificial bones that mimic natural bones. In this study, computed tomography (CT)-guided …