Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …

The term 'nonsense-mediated mRNA decay'(NMD) was initially coined to describe the
translation-dependent degradation of mRNAs harboring premature termination codons …

Antigen presentation by the human leukocyte antigen (HLA) on the cell surface is critical for
the transduction of the immune signal toward cytotoxic T lymphocytes. DNA damage …

Nonsense-mediated messenger RNA (mRNA) decay (NMD) has been intensively studied as
a surveillance pathway that degrades erroneous transcripts arising from mutations or RNA …

Nonsense-mediated mRNA decay (NMD) protects cells from the toxic and potentially
dominant effects of truncated proteins. Targeting of mRNAs with early stop codons is …

The exon junction complex (EJC) becomes an increasingly important regulator of early gene
expression in the central nervous system (CNS) and other tissues. The EJC is comprised of …

Cell fate is shaped by a unique gene expression program, which reflects the concerted
action of multilayered precise regulation. Substantial research attention has been paid to the …

Nonsense-mediated mRNA decay (NMD) is a eukaryotic RNA decay pathway with roles in
cellular stress responses, differentiation, and viral defense. It functions in both quality control …

Nonsense-mediated mRNA decay (NMD) is a highly conserved regulatory mechanism of
post-transcriptional gene expression in eukaryotic cells. NMD plays essential roles in mRNA …

Soft-tissue sarcomas (STSs) are a rare and diverse group of mesenchymal cancers plagued
with aggression, poor response to systemic therapy, and high rates of recurrence. Although …