It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer
cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better …

Introduction 3. Paracrine soluble factors regulating hepatic stellate cell activation 3.1.
Transforming growth factor-beta 3.2. Tumor necrosis factor-alpha 3.3. Endothelins 3.4 …

Activated macrophages regulate fibrogenesis by providing cytokines and growth factors that
modulate the proliferation and collagen synthesis of fibroblasts. However, macrophages can …

For the first time in history, populations in affluent countries may concomitantly indulge in
rich food and physical idleness. Various combinations of obesity, diabetes, and …

Nonalcoholic fatty liver disease is now recognized as the most common liver disease in the
United States, with a prevalence of approximately 5% in the general population and up to …

Background & Aims: The ligand-dependent transcription factor peroxisome proliferator-
activated receptor γ (PPARγ) is expressed in hepatic stellate cells (HSC), and its …

Liver fibrosis is the hallmark of every chronic liver disease. It is also the major factor of
morbidity and mortality due to the development of cirrhosis and its complications including …

Background & Aims: Proliferation and migration of hepatic stellate cells (HSCs) and
expression of chemokines are involved in the pathogenesis of liver inflammation and …

Leptin upregulates collagen expression in hepatic stellate cells (HSCs), but the possible
modulation of other actions has not been elucidated. The aim of this study was to investigate …

BACKGROUND/AIMS: Hepatic fibrogenesis, a consequence of chronic liver tissue damage,
is characterized by activation of the hepatic stellate cells (HSC). Silybin has been shown to …