The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …

RNA base editing refers to the rewriting of genetic information within an intact RNA molecule
and serves various functions, such as evasion of the endogenous immune system and …

Clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editors
are powerful tools in biology and hold great promise for the treatment of human diseases …

ABSTRACT RNA editing by cytosine and adenosine deaminases changes the identity of the
edited bases. While cytosines are converted to uracils, adenines are converted to inosines. If …

Genetic medicine is offering hope as new therapies are emerging for many previously
untreatable diseases. The eye is at the forefront of these advances, as exemplified by the …

Site-directed RNA base editing enables the transient and dosable change of genetic
information and represents a recent strategy to manipulate cellular processes, paving ways …

Drug-ID is a novel method applying proximity biotinylation to identify drug–protein
interactions inside living cells. The covalent conjugation of a drug with a biotin ligase …

With the advancement of sequencing technologies and bioinformatics, over than 170
different RNA modifications have been identified. However, only a few of these modifications …

RNA base editing relies on the introduction of adenosine-to-inosine changes into target
RNAs in a highly programmable manner in order to repair disease-causing mutations. Here …

Over recent years, zinc-dependent deaminases have attracted increasing interest as key
components of nucleic acid editing tools that can generate point mutations at specific sites in …