Use of gene expression studies to investigate the human immunological response to malaria infection
Background Transcriptional profiling of the human immune response to malaria has been
used to identify diagnostic markers, understand the pathogenicity of severe disease and …
used to identify diagnostic markers, understand the pathogenicity of severe disease and …
Liposomes containing monophosphoryl lipid A and QS-21 serve as an effective adjuvant for soluble circumsporozoite protein malaria vaccine FMP013
Malaria caused by Plasmodium falciparum continues to threaten millions of people living in
the tropical parts of the world. A vaccine that confers sterile and life-long protection remains …
the tropical parts of the world. A vaccine that confers sterile and life-long protection remains …
A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts
JA Gabelich, J Grützke, F Kirscht, O Popp… - PLoS …, 2022 - journals.plos.org
Protein export and host membrane remodeling are crucial for multiple Plasmodium species
to establish a niche in infected hosts. To better understand the contribution of these …
to establish a niche in infected hosts. To better understand the contribution of these …
Dissecting The role of Plasmodium metacaspase-2 in malaria gametogenesis and sporogony
The family of apicomplexan specific proteins contains caspases–like proteins called
“metacaspases”. These enzymes are present in the malaria parasite but absent in human; …
“metacaspases”. These enzymes are present in the malaria parasite but absent in human; …
Flp/FRT-mediated disruption of ptex150 and exp2 in Plasmodium falciparum sporozoites inhibits liver-stage development
R McConville, JMM Krol, RWJ Steel… - Proceedings of the …, 2024 - National Acad Sciences
Plasmodium falciparum causes severe malaria and assembles a protein translocon (PTEX)
complex at the parasitophorous vacuole membrane (PVM) of infected erythrocytes, through …
complex at the parasitophorous vacuole membrane (PVM) of infected erythrocytes, through …
Plasmodium vivax Tryptophan Rich Antigen PvTRAg36.6 Interacts with PvETRAMP and PvTRAg56.6 Interacts with PvMSP7 during Erythrocytic Stages of the Parasite
K Tyagi, ME Hossain, V Thakur, P Aggarwal… - PLoS …, 2016 - journals.plos.org
Plasmodium vivax is most wide spread and a neglected malaria parasite. There is a lack of
information on parasite biology of this species. Genome of this parasite encodes for the …
information on parasite biology of this species. Genome of this parasite encodes for the …
More than just antibodies: protective mechanisms of a mucosal vaccine against fish pathogen Flavobacterium columnare
A recently developed attenuated vaccine for Flavobacterium columnare has been
demonstrated to provide superior protection for channel catfish, Ictalurus punctatus, against …
demonstrated to provide superior protection for channel catfish, Ictalurus punctatus, against …
Identification and characterization of nuclear localization signals in the circumsporozoite protein of Plasmodium falciparum
AN Shrikondawar, K Chennoju, DK Ghosh… - FEBS …, 2024 - Wiley Online Library
Secretory proteins of Plasmodium exhibit differential spatial and functional activity within the
host cell nucleus. However, the nuclear localization signals (NLSs) for these proteins remain …
host cell nucleus. However, the nuclear localization signals (NLSs) for these proteins remain …
Dual RNA Sequencing Meta-analysis in Plasmodium Infection Identifies Host-Parasite Interactions
P Mukherjee, G Burgio, E Heitlinger - Msystems, 2021 - Am Soc Microbiol
ABSTRACT Dual RNA sequencing (RNA-Seq) is the simultaneous transcriptomic analysis of
interacting symbionts, for example, in malaria. Potential cross-species interactions identified …
interacting symbionts, for example, in malaria. Potential cross-species interactions identified …
Plasmodium falciparum exoerythrocytic forms require the PTEX translocon for development in human hepatocytes
R McConville, J Krol, R Steel, M O'Neill, B Davey… - 2023 - researchsquare.com
Plasmodium falciparum assembles a protein translocon (PTEX) at the parasitophorous
vacuole membrane (PVM) of infected erythrocytes, through which several hundred proteins …
vacuole membrane (PVM) of infected erythrocytes, through which several hundred proteins …