Use of gene expression studies to investigate the human immunological response to malaria infection

SH Hodgson, J Muller, HE Lockstone, AVS Hill… - Malaria Journal, 2019 - Springer
Background Transcriptional profiling of the human immune response to malaria has been
used to identify diagnostic markers, understand the pathogenicity of severe disease and …

Liposomes containing monophosphoryl lipid A and QS-21 serve as an effective adjuvant for soluble circumsporozoite protein malaria vaccine FMP013

CJ Genito, Z Beck, TW Phares, F Kalle, KJ Limbach… - Vaccine, 2017 - Elsevier
Malaria caused by Plasmodium falciparum continues to threaten millions of people living in
the tropical parts of the world. A vaccine that confers sterile and life-long protection remains …

A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts

JA Gabelich, J Grützke, F Kirscht, O Popp… - PLoS …, 2022 - journals.plos.org
Protein export and host membrane remodeling are crucial for multiple Plasmodium species
to establish a niche in infected hosts. To better understand the contribution of these …

Dissecting The role of Plasmodium metacaspase-2 in malaria gametogenesis and sporogony

V Kumari, KM Prasad, I Kalia, G Sindhu… - Emerging Microbes & …, 2022 - Taylor & Francis
The family of apicomplexan specific proteins contains caspases–like proteins called
“metacaspases”. These enzymes are present in the malaria parasite but absent in human; …

Flp/FRT-mediated disruption of ptex150 and exp2 in Plasmodium falciparum sporozoites inhibits liver-stage development

R McConville, JMM Krol, RWJ Steel… - Proceedings of the …, 2024 - National Acad Sciences
Plasmodium falciparum causes severe malaria and assembles a protein translocon (PTEX)
complex at the parasitophorous vacuole membrane (PVM) of infected erythrocytes, through …

Plasmodium vivax Tryptophan Rich Antigen PvTRAg36.6 Interacts with PvETRAMP and PvTRAg56.6 Interacts with PvMSP7 during Erythrocytic Stages of the Parasite

K Tyagi, ME Hossain, V Thakur, P Aggarwal… - PLoS …, 2016 - journals.plos.org
Plasmodium vivax is most wide spread and a neglected malaria parasite. There is a lack of
information on parasite biology of this species. Genome of this parasite encodes for the …

More than just antibodies: protective mechanisms of a mucosal vaccine against fish pathogen Flavobacterium columnare

D Zhang, W Thongda, C Li, H Zhao, BH Beck… - Fish & Shellfish …, 2017 - Elsevier
A recently developed attenuated vaccine for Flavobacterium columnare has been
demonstrated to provide superior protection for channel catfish, Ictalurus punctatus, against …

Identification and characterization of nuclear localization signals in the circumsporozoite protein of Plasmodium falciparum

AN Shrikondawar, K Chennoju, DK Ghosh… - FEBS …, 2024 - Wiley Online Library
Secretory proteins of Plasmodium exhibit differential spatial and functional activity within the
host cell nucleus. However, the nuclear localization signals (NLSs) for these proteins remain …

Dual RNA Sequencing Meta-analysis in Plasmodium Infection Identifies Host-Parasite Interactions

P Mukherjee, G Burgio, E Heitlinger - Msystems, 2021 - Am Soc Microbiol
ABSTRACT Dual RNA sequencing (RNA-Seq) is the simultaneous transcriptomic analysis of
interacting symbionts, for example, in malaria. Potential cross-species interactions identified …

Plasmodium falciparum exoerythrocytic forms require the PTEX translocon for development in human hepatocytes

R McConville, J Krol, R Steel, M O'Neill, B Davey… - 2023 - researchsquare.com
Plasmodium falciparum assembles a protein translocon (PTEX) at the parasitophorous
vacuole membrane (PVM) of infected erythrocytes, through which several hundred proteins …