[HTML][HTML] Global burden of Clostridium difficile infections: a systematic review and meta-analysis

E Balsells, T Shi, C Leese, I Lyell, J Burrows… - Journal of global …, 2019 - ncbi.nlm.nih.gov
Background Clostridium difficile is a leading cause of morbidity and mortality in several
countries. However, there are limited evidence characterizing its role as a global public …

Impact of microbial derived secondary bile acids on colonization resistance against Clostridium difficile in the gastrointestinal tract

JA Winston, CM Theriot - Anaerobe, 2016 - Elsevier
Clostridium difficile is an anaerobic, Gram positive, spore-forming bacillus that is the leading
cause of nosocomial gastroenteritis. Clostridium difficile infection (CDI) is associated with …

Clostridium difficile infection: an epidemiology update

AC De Roo, SE Regenbogen - Clinics in colon and rectal …, 2020 - thieme-connect.com
Clostridium (reclassified as “Clostridioides”) difficile infection (CDI) is a healthcare-
associated infection and significant source of potentially preventable morbidity, recurrence …

Ursodeoxycholic acid (UDCA) mitigates the host inflammatory response during Clostridioides difficile infection by altering gut bile acids

JA Winston, AJ Rivera, J Cai, R Thanissery… - Infection and …, 2020 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is associated with increasing morbidity and mortality
posing an urgent threat to public health. Recurrence of CDI after successful treatment with …

Reuterin disrupts Clostridioides difficile metabolism and pathogenicity through reactive oxygen species generation

MA Engevik, HA Danhof, R Shrestha… - Gut …, 2020 - Taylor & Francis
Antibiotic resistance is one of the world's greatest public health challenges and adjunct
probiotic therapies are strategies that could lessen this burden. Clostridioides difficile …

Low Risk of Primary Clostridium difficile Infection With Tetracyclines: A Systematic Review and Metaanalysis

R Tariq, J Cho, S Kapoor, R Orenstein… - Clinical Infectious …, 2018 - academic.oup.com
Background The choice of antibiotics for systemic infections in patients with a high risk of
Clostridium difficile infection (CDI) remains a clinical practice dilemma. Although some …

[HTML][HTML] Rapid diagnostics for bloodstream infections: a primer for infection preventionists

CE Edmiston, R Garcia, M Barnden, B DeBaun… - American journal of …, 2018 - Elsevier
Accurate and rapid antimicrobial susceptibility testing with pathogen identification in
bloodstream infections is critical to life results for early sepsis intervention. Advancements in …

Omadacycline gut microbiome exposure does not induce Clostridium difficile proliferation or toxin production in a model that simulates the proximal, medial, and distal …

IB Moura, AM Buckley, D Ewin… - Antimicrobial agents …, 2019 - Am Soc Microbiol
ABSTRACT A clinically reflective model of the human colon was used to investigate the
effects of the broad-spectrum antibiotic omadacycline on the gut microbiome and the …

Hospital-level high-risk antibiotic use in relation to hospital-associated Clostridioides difficile infections: retrospective analysis of 2016–2017 data from US hospitals

YP Tabak, A Srinivasan, CY Kalvin… - Infection Control & …, 2019 - cambridge.org
Objective: Antibiotics are widely used by all specialties in the hospital setting. We evaluated
previously defined high-risk antibiotic use in relation to Clostridioides difficile infections …

Association of SARS-CoV-2 status and antibiotic-resistant bacteria with inadequate empiric therapy in hospitalized patients: a US multicenter cohort evaluation (July …

KA Bauer, LA Puzniak, KC Yu, KP Klinker… - BMC Infectious …, 2023 - Springer
Background Antibiotic usage and antibiotic resistance (ABR) patterns changed during the
COVID-19 pandemic. Inadequate empiric antibiotic therapy (IET) is a significant public …