Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

N6-methyladenosine reader YTHDF family in biological processes: structures, roles, and mechanisms

L Chen, Y Gao, S Xu, J Yuan, M Wang, T Li… - Frontiers in …, 2023 - frontiersin.org
As the most abundant and conserved internal modification in eukaryote RNAs, N6-
methyladenosine (m6A) is involved in a wide range of physiological and pathological …

METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

L Wang, J Wang, P Yu, J Feng, G Xu, X Zhao… - Nature …, 2022 - nature.com
RNA m6A modification is the most widely distributed RNA methylation and is closely related
to various pathophysiological processes. Although the benefit of regular exercise on the …

Pan-cancer analysis shows that ALKBH5 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including gliomas

C Wei, B Wang, D Peng, X Zhang, Z Li, L Luo… - Frontiers in …, 2022 - frontiersin.org
Background AlkB homolog 5 (ALKBH5) is a N6-methyladenosine (m6A) demethylase
associated with the development, growth, and progression of multiple cancer types …

YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner

H Chen, Y Yu, M Yang, H Huang, S Ma, J Hu, Z Xi… - Cell & bioscience, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) is the most common post-transcriptional
modification at the RNA level. However, the exact molecular mechanisms of m6A epigenetic …

YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner

Z Li, M Teng, Y Jiang, L Zhang, X Luo, Y Liao… - Frontiers in …, 2022 - frontiersin.org
Background Previous studies have confirmed that the bacterium Treponema pallidum (TP)
or its proteins provide signals to macrophages that induce an inflammatory response; …

The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

Z Chen, X Zhong, M Xia, J Zhong - Molecular Therapy-Nucleic Acids, 2021 - cell.com
YTHDF1 is the most versatile and powerful reader protein of N 6-methyladenosine (m6A)-
modified RNA, and it can recognize both G (m6A) C and A (m6A) C RNAs as ligands without …

METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner

R Zhang, Y Qu, Z Ji, C Hao, Y Su, Y Yao, W Zuo… - Cellular & molecular …, 2022 - Springer
Background METTL3 is the core catalytic enzyme in m6A and is involved in a variety of
cardiovascular diseases. However, whether and how METTL3 plays a role during …

Increased m6A-RNA methylation and FTO suppression is associated with myocardial inflammation and dysfunction during endotoxemia in mice

PK Dubey, M Patil, S Singh, S Dubey, P Ahuja… - Molecular and Cellular …, 2022 - Springer
Endotoxemia triggers life-threatening immune and cardiovascular response that leads to
tissue damage, multi-organ failure, and death. The understanding of underlying molecular …

m6A methylation in cardiovascular diseases: from mechanisms to therapeutic potential

L Li, N Xu, J Liu, Z Chen, X Liu, J Wang - Frontiers in genetics, 2022 - frontiersin.org
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide.
Recent studies have shown that n6-methyladenosine (m6A) plays a major role in …