Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

Oxidative stress exacerbates brain damage following ischemia-reperfusion and traumatic
brain injury (TBI). Management of TBI and critically ill patients commonly involves use of …

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs)(iPSC-CMs) are
a promising cell source for myocardial regeneration, disease modeling and drug …

Maternal alcohol exposure during pregnancy can substantially impact the development of
the fetus, causing a range of symptoms, known as fetal alcohol spectrum disorders (FASDs) …

Alzheimer's disease (AD) is a predominantly heterogeneous disease with a highly complex
pathobiology. The presence of amyloid-beta (Aβ) depositions and the accumulation of …

Background Recently, the safety of repeated and lengthy anesthesia administration has
been called into question, a subset of these animal studies demonstrated that anesthetics …

Brain development is a dynamic and lengthy process that includes cell proliferation,
migration, neurogenesis, gliogenesis, synaptogenesis, and pruning. Disruption of any of …

Emerging evidence from human epidemiologic and animal studies has demonstrated that
developmental anesthesia neurotoxicity could cause long-term cognitive deficits and …

Background. Propofol (PPF) has been shown in studies to cause cognitive impairment and
neuronal cell death in developing animals. PPF has been demonstrated to decrease the …

Studies have shown that propofol-induced neurotoxicity is mediated by disruption of
mitochondrial fission and fusion, leading to an imbalance in energy supply for developing …