Since the advent of penicillin, humans have known about and explored the phenomenon of
bacterial inhibition via antibiotics. However, with changes in the global environment and the …

Many biological activities originate from interactions between small-molecule ligands and
their protein targets. A detailed structural and physico-chemical characterization of these …

With antibiotic resistance mechanisms increasing in diversity and spreading among
bacterial pathogens, the development of new classes of antibacterial agents against …

Sulfonyl group-containing compounds constitute an important class of therapeutical agents
in medicinal chemistry presumably because of the tense chemical structure and functionality …

The widespread emergence of resistant bacterial strains is becoming a serious threat to
public health. This thus signifies the need for the development of new antibacterial agents …

Rational design is applied in the discovery of novel lead drugs. Its rapid development is
mainly attributed to the tremendous advancements in the computer science, statistics …

Structures of several dozen of known antibacterial, antifungal or antiprotozoal agents are
based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial …

We have designed, synthesized, and evaluated 5-benzylidenerhodanine-and 5-
benzylidenethiazolidine-2, 4-dione-based compounds as inhibitors of bacterial enzyme …

Reported here is a simple and practical functionalization of primary sulfonamides, by means
of a pyrylium salt (Pyry‐BF4), with nucleophiles. This simple reagent activates the poorly …

The range of antibiotic therapy for the control of bacterial infections is becoming increasingly
limited because of the rapid rise in multidrug resistance in clinical bacterial isolates. A few …