Growth hormone and insulin-like growth factor 1 regulation of nonalcoholic fatty liver disease

LE Dichtel, J Cordoba-Chacon… - The Journal of Clinical …, 2022 - academic.oup.com
Patients with obesity have a high prevalence of nonalcoholic fatty liver disease (NAFLD),
representing a spectrum of simple steatosis to nonalcoholic steatohepatitis (NASH), without …

Metabolic diseases and healthy aging: identifying environmental and behavioral risk factors and promoting public health

K Zhang, Y Ma, Y Luo, Y Song, G Xiong, Y Ma… - Frontiers in Public …, 2023 - frontiersin.org
Aging is a progressive and irreversible pathophysiological process that manifests as the
decline in tissue and cellular functions, along with a significant increase in the risk of various …

Hypothalamus and post-traumatic stress disorder: a review

P Raise-Abdullahi, M Meamar, AA Vafaei, M Alizadeh… - Brain sciences, 2023 - mdpi.com
Humans have lived in a dynamic environment fraught with potential dangers for thousands
of years. While fear and stress were crucial for the survival of our ancestors, today, they are …

Towards understanding the direct and indirect actions of growth hormone in controlling hepatocyte carbohydrate and lipid metabolism

MC Vázquez-Borrego, M del Rio-Moreno, RD Kineman - Cells, 2021 - mdpi.com
Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays
an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to …

Growth hormone action in somatostatin neurons regulates anxiety and fear memory

WO Dos Santos, VAL Juliano, FM Chaves… - Journal of …, 2023 - Soc Neuroscience
Dysfunctions in growth hormone (GH) secretion increase the prevalence of anxiety and
other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been …

Effects of the isolated and combined ablation of growth hormone and IGF-1 receptors in somatostatin neurons

FM Chaves, F Wasinski, MR Tavares… - …, 2022 - academic.oup.com
Hypophysiotropic somatostatin (SST) neurons in the periventricular hypothalamic area
express growth hormone (GH) receptor (GHR) and are frequently considered as the key …

Increased GH secretion and body growth in mice carrying ablation of IGF-1 receptor in GH-releasing hormone cells

DO Gusmao, ME de Sousa, MR Tavares… - …, 2022 - academic.oup.com
Growth hormone (GH) secretion is controlled by short and long negative feedback loops. In
this regard, both GH (short-loop feedback) and insulin-like growth factor 1 (IGF-1; long-loop …

Ablation of growth hormone receptor in GABAergic neurons leads to increased pulsatile growth hormone secretion

WO Dos Santos, F Wasinski, MR Tavares… - …, 2022 - academic.oup.com
Growth hormone (GH) acts in several hypothalamic neuronal populations to modulate
metabolism and the autoregulation of GH secretion via negative-feedback loops. However …

Mechanisms mediating the impact of maternal obesity on offspring hypothalamic development and later function

IC Furigo, L Dearden - Frontiers in endocrinology, 2022 - frontiersin.org
As obesity rates have risen around the world, so to have pregnancies complicated by
maternal obesity. Obesity during pregnancy is not only associated with negative health …

Fasting and prolonged food restriction differentially affect GH secretion independently of GH receptor signaling in AgRP neurons

ME de Sousa, DO Gusmao… - Journal of …, 2024 - Wiley Online Library
Growth hormone (GH) receptor (GHR) is abundantly expressed in neurons that co‐release
the agouti‐related protein (AgRP) and neuropeptide Y (NPY) in the arcuate nucleus of the …