Growth hormone and insulin-like growth factor 1 regulation of nonalcoholic fatty liver disease
LE Dichtel, J Cordoba-Chacon… - The Journal of Clinical …, 2022 - academic.oup.com
Patients with obesity have a high prevalence of nonalcoholic fatty liver disease (NAFLD),
representing a spectrum of simple steatosis to nonalcoholic steatohepatitis (NASH), without …
representing a spectrum of simple steatosis to nonalcoholic steatohepatitis (NASH), without …
Metabolic diseases and healthy aging: identifying environmental and behavioral risk factors and promoting public health
K Zhang, Y Ma, Y Luo, Y Song, G Xiong, Y Ma… - Frontiers in Public …, 2023 - frontiersin.org
Aging is a progressive and irreversible pathophysiological process that manifests as the
decline in tissue and cellular functions, along with a significant increase in the risk of various …
decline in tissue and cellular functions, along with a significant increase in the risk of various …
Hypothalamus and post-traumatic stress disorder: a review
Humans have lived in a dynamic environment fraught with potential dangers for thousands
of years. While fear and stress were crucial for the survival of our ancestors, today, they are …
of years. While fear and stress were crucial for the survival of our ancestors, today, they are …
Towards understanding the direct and indirect actions of growth hormone in controlling hepatocyte carbohydrate and lipid metabolism
MC Vázquez-Borrego, M del Rio-Moreno, RD Kineman - Cells, 2021 - mdpi.com
Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays
an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to …
an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to …
Growth hormone action in somatostatin neurons regulates anxiety and fear memory
WO Dos Santos, VAL Juliano, FM Chaves… - Journal of …, 2023 - Soc Neuroscience
Dysfunctions in growth hormone (GH) secretion increase the prevalence of anxiety and
other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been …
other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been …
Effects of the isolated and combined ablation of growth hormone and IGF-1 receptors in somatostatin neurons
FM Chaves, F Wasinski, MR Tavares… - …, 2022 - academic.oup.com
Hypophysiotropic somatostatin (SST) neurons in the periventricular hypothalamic area
express growth hormone (GH) receptor (GHR) and are frequently considered as the key …
express growth hormone (GH) receptor (GHR) and are frequently considered as the key …
Increased GH secretion and body growth in mice carrying ablation of IGF-1 receptor in GH-releasing hormone cells
DO Gusmao, ME de Sousa, MR Tavares… - …, 2022 - academic.oup.com
Growth hormone (GH) secretion is controlled by short and long negative feedback loops. In
this regard, both GH (short-loop feedback) and insulin-like growth factor 1 (IGF-1; long-loop …
this regard, both GH (short-loop feedback) and insulin-like growth factor 1 (IGF-1; long-loop …
Ablation of growth hormone receptor in GABAergic neurons leads to increased pulsatile growth hormone secretion
Growth hormone (GH) acts in several hypothalamic neuronal populations to modulate
metabolism and the autoregulation of GH secretion via negative-feedback loops. However …
metabolism and the autoregulation of GH secretion via negative-feedback loops. However …
Mechanisms mediating the impact of maternal obesity on offspring hypothalamic development and later function
IC Furigo, L Dearden - Frontiers in endocrinology, 2022 - frontiersin.org
As obesity rates have risen around the world, so to have pregnancies complicated by
maternal obesity. Obesity during pregnancy is not only associated with negative health …
maternal obesity. Obesity during pregnancy is not only associated with negative health …
Fasting and prolonged food restriction differentially affect GH secretion independently of GH receptor signaling in AgRP neurons
ME de Sousa, DO Gusmao… - Journal of …, 2024 - Wiley Online Library
Growth hormone (GH) receptor (GHR) is abundantly expressed in neurons that co‐release
the agouti‐related protein (AgRP) and neuropeptide Y (NPY) in the arcuate nucleus of the …
the agouti‐related protein (AgRP) and neuropeptide Y (NPY) in the arcuate nucleus of the …