Splicing regulation by long noncoding RNAs

N Romero-Barrios, MF Legascue… - Nucleic acids …, 2018 - academic.oup.com
Massive high-throughput sequencing techniques allowed the identification of thousands of
noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in …

[HTML][HTML] SR proteins: binders, regulators, and connectors of RNA

S Jeong - Molecules and cells, 2017 - Elsevier
Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as
constitutive and alternative splicing regulators. As splicing is linked to transcriptional and …

The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation

V Tripathi, JD Ellis, Z Shen, DY Song, Q Pan, AT Watt… - Molecular cell, 2010 - cell.com
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased
transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate …

Regulation of splicing by SR proteins and SR protein-specific kinases

Z Zhou, XD Fu - Chromosoma, 2013 - Springer
Genomic sequencing reveals similar but limited numbers of protein-coding genes in different
genomes, which begs the question of how organismal diversities are generated. Alternative …

SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export

M Müller-McNicoll, V Botti… - Genes & …, 2016 - genesdev.cshlp.org
Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by
specific adaptor proteins. How and why cells use numerous different export adaptors is …

The SR protein family of splicing factors: master regulators of gene expression

JC Long, JF Caceres - Biochemical Journal, 2009 - portlandpress.com
The SR protein family comprises a number of phylogenetically conserved and structurally
related proteins with a characteristic domain rich in arginine and serine residues, known as …

The RNAissance family: SR proteins as multifaceted regulators of gene expression

JM Howard, JR Sanford - Wiley Interdisciplinary Reviews: RNA, 2015 - Wiley Online Library
Serine and arginine‐rich (SR) proteins play multiple roles in the eukaryotic gene expression
pathway. Initially described as constitutive and alternative splicing factors, now it is clear that …

WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing

EM Amin, S Oltean, J Hua, MVR Gammons… - Cancer cell, 2011 - cell.com
Angiogenesis is regulated by the balance of proangiogenic VEGF 165 and antiangiogenic
VEGF 165 b splice isoforms. Mutations in WT1, the Wilms' tumor suppressor gene, suppress …

Splicing-factor alterations in cancers

O Anczuków, AR Krainer - Rna, 2016 - rnajournal.cshlp.org
Tumor-associated alterations in RNA splicing result either from mutations in splicing-
regulatory elements or changes in components of the splicing machinery. This review …

hnRNP A1 relocalization to the stress granules reflects a role in the stress response

S Guil, JC Long, JF Cáceres - Molecular and cellular biology, 2006 - Am Soc Microbiol
Abstract hnRNP A1 is a nucleocytoplasmic shuttling protein that is involved in many aspects
of mRNA metabolism. We have previously shown that activation of the p38 stress-signaling …